Results 1 to 10 of about 18,631,052 (336)

Three-Dimensional Culture Systems in Neuroblastoma Research [PDF]

Organoids
Basic and translational cancer biology research requires model systems that recapitulate the features of human tumors. While two-dimensional (2D) cell cultures have been foundational and allowed critical advances, they lack the organizational complexity,
Piotr Jung, Adam J. Wolpaw
doaj   +5 more sources

Three Dimensional Culture of Human Renal Cell Carcinoma Organoids. [PDF]

PLoS ONE, 2015
Renal cell carcinomas arise from the nephron but are heterogeneous in disease biology, clinical behavior, prognosis, and response to systemic therapy. Development of patient-specific in vitro models that efficiently and faithfully reproduce the in vivo ...
Cynthia A Batchelder, Michele L Martinez, Nadire Duru, Frederick J Meyers, Alice F Tarantal   +4 more
doaj   +2 more sources

Effects of IGF-1 on the Three-Dimensional Culture of Ovarian Preantral Follicles and Superovulation Rates in Mice

Biology, 2022
Insulin-like growth factor-1 (IGF-1) plays a crucial role during folliculogenesis, which has been demonstrated by previous research. However, the optimal IGF-1 dosage in the three-dimensional (3D) culture system is unknown. Mouse secondary follicles (140–
Shizhen Dai, Hanxue Zhang, Feng Yang, Wei Shang, Shenming Zeng   +4 more
doaj   +2 more sources

Characterization of a Bioink Combining Extracellular Matrix-like Hydrogel with Osteosarcoma Cells: Preliminary Results

Gels, 2023
Three-dimensional (3D) bioprinting allows the production of artificial 3D cellular microenvironments thanks to the controlled spatial deposition of bioinks.
Giada Loi, Gaia Stucchi, Franca Scocozza, Laura Cansolino, Francesca Cadamuro, Elena Delgrosso, Federica Riva, Cinzia Ferrari, Laura Russo, Michele Conti   +9 more
doaj   +1 more source

Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture. [PDF]

PLoS ONE, 2015
In renal collecting duct (CD) principal cells (PCs), vasopressin (VP) acts through its receptor, V2R, to increase intracellular cAMP leading to phosphorylation and apical membrane accumulation of the water channel aquaporin 2 (AQP2).
William L Rice, Wei Li, Fahmy Mamuya, Mary McKee, Teodor G Păunescu, Hua A Jenny Lu   +5 more
doaj   +1 more source

Advances in tissue engineering of cancer microenvironment-from three-dimensional culture to three-dimensional printing

SLAS Technology, 2023
Cancer treatment development is a complex process, with tumor heterogeneity and inter-patient variations limiting the success of therapeutic intervention.
Joana Rita Oliveira Faria Marques, Patricia González-Alva, Ruby Yu-Tong Lin, Beatriz Ferreira Fernandes, Akhilanand Chaurasia, Nileshkumar Dubey   +5 more
doaj   +1 more source

Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury

Stem cell research & therapeutics, 2020
Background Exosomes derived from mesenchymal stem cells (MSC-exos) have been demonstrated with great potential in the treatment of multiple human diseases including acute kidney injury (AKI) by virtue of their intrinsic cargoes.
Jing-Yuan Cao, Bin Wang, Tao-Tao Tang, Lin-Li Lv, Zhao-ying Ding, Zuo-Lin Li, Ruoyu Hu, Q. Wei, Anran Shen, Yuqi Fu, Bi-Cheng Liu   +10 more
semanticscholar   +1 more source

The Metabolic Changes between Monolayer (2D) and Three-Dimensional (3D) Culture Conditions in Human Mesenchymal Stem/Stromal Cells Derived from Adipose Tissue

Cells, 2023
Introduction: One of the key factors that may influence the therapeutic potential of mesenchymal stem/stromal cells (MSCs) is their metabolism. The switch between mitochondrial respiration and glycolysis can be affected by many factors, including the ...
Paulina Rybkowska, Klaudia Radoszkiewicz, Maria Kawalec, Dorota Dymkowska, Barbara Zabłocka, Krzysztof Zabłocki, Anna Sarnowska   +6 more
doaj   +1 more source

Patient-Derived Organoids: The Beginning of a New Era in Ovarian Cancer Disease Modeling and Drug Sensitivity Testing

Biomedicines, 2022
Ovarian cancer (OC) is the leading cause of death from gynecological malignancies. Despite great advances in treatment strategies, therapeutic resistance and the gap between preclinical data and actual clinical efficacy justify the necessity of ...
Iason Psilopatis, Alexandros G. Sykaras, Georgios Mandrakis, Kleio Vrettou, Stamatios Theocharis   +4 more
doaj   +1 more source

Three-Dimensional Culture System of Cancer Cells Combined with Biomaterials for Drug Screening

Cancers, 2020
Simple Summary For the research and development of drug discovery, it is of prime importance to construct the three-dimensional (3D) tissue models in vitro.
Teruki Nii, K. Makino, Y. Tabata
semanticscholar   +1 more source