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Three-dimensional cell culture for the study of nasal polyps [PDF]
Brazilian Journal of Otorhinolaryngology, 2022 Objectives: Three-dimensional (3D) cell cultures have many applications such as stem cell biology research, new drug discovery, cancer, and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
Carolina Nunes França +5 more
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Three-Dimensional Cell Culture: A Breakthrough in Vivo [PDF]
International Journal of Molecular Sciences, 2015 Cell culture is an important tool for biological research. Two-dimensional cell culture has been used for some time now, but growing cells in flat layers on plastic surfaces does not accurately model the in vivo state. As compared to the two-dimensional case, the three-dimensional (3D) cell culture allows biological cells to grow or interact with their
Delphine Antoni +2 more
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Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications
Stem Cells International, 2021 Cell culture is one of the most core and fundamental techniques employed in the fields of biology and medicine. At present, although the two-dimensional cell culture method is commonly used in vitro, it is quite different from the cell growth ...
Xiaowen Wu +4 more
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Three Dimensional Culture of Human Renal Cell Carcinoma Organoids. [PDF]
PLoS ONE, 2015 Renal cell carcinomas arise from the nephron but are heterogeneous in disease biology, clinical behavior, prognosis, and response to systemic therapy. Development of patient-specific in vitro models that efficiently and faithfully reproduce the in vivo ...
Cynthia A Batchelder +4 more
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Implications of Three-Dimensional Cell Culture in Cancer Therapeutic Research [PDF]
Frontiers in Oncology, 2022 Replicating the naturalistic biomechanical milieu of cells is a primary requisite to uncover the fundamental life processes. The native milieu is significantly not replicated in the two-dimensional (2D) cell cultures.
Kolluri Poornima +11 more
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Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development
Micromachines, 2021 Three-dimensional multicellular spheroids (MCSs) have received extensive attention in the field of biomedicine due to their ability to simulate the structure and function of tissues in vivo more accurately than traditional in vitro two-dimensional models
Honglin Shen +5 more
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Biomedicines, 2022 Ovarian cancer (OC) is the leading cause of death from gynecological malignancies. Despite great advances in treatment strategies, therapeutic resistance and the gap between preclinical data and actual clinical efficacy justify the necessity of ...
Iason Psilopatis +4 more
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Three-Dimensional Cell Cultures in Toxicology [PDF]
Biotechnology and Genetic Engineering Reviews, 2009 Toxicity testing with animals is expensive, ethically controversial, and not always predictive of the human response. Cell-based assays are regarded as an alternative. However, conventional two-dimensional cell cultures do not reproduce the tissue architecture in vivo, and do not forecast organ-specific toxicity.
Francesco, Pampaloni, Ernst, Stelzer
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Mxi1 influences cyst formation in three-dimensional cell culture [PDF]
BMB Reports, 2012 Cyst formation is a major characteristic of ADPKD and iscaused by the abnormal proliferation of epithelial cells. Renalcyst formation disrupts renal function and induces diversecomplications.
Yeon Joo Yook +9 more
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Three dimensional microcarrier system in mesenchymal stem cell culture: a systematic review
Cell & Bioscience, 2020 Stem cell-based regenerative medicine is a promising approach for tissue reconstruction. However, a large number of cells are needed in a typical clinical study, where conventional monolayer cultures might pose a limitation for scale-up.
Benson Koh +6 more
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