Results 51 to 60 of about 20,905,469 (291)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Peptide hydrogels – versatile matrices for 3D cell culture in cancer medicine

Frontiers in Oncology, 2015
Traditional two-dimensional (2D) cell culture systems have contributed tremendously to our understanding of cancer biology but have significant limitations in mimicking in vivo conditions such as the tumor microenvironment.
Peter eWorthington, Peter eWorthington, Darrin John Pochan, Sigrid A Langhans   +3 more
doaj   +1 more source

Effects of TGF-β1 on the migration of oral cancer-associated fibroblasts in two and three dimensional co-culture models

口腔疾病防治, 2020
Objective To observe the effect of transforming growth factor-β1 (TGF-β1) on the migration of oral carcinoma associated fibroblasts (CAFs) with two-dimensional culture model and three-dimensional model.Methods Under two-dimensional culture conditions ...
YANG Jin, WU Feifei, GAO Qinghong, LI Xiaoyu, MANABU Kato, CHENG Ran, ZHOU Hongmei   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity

Biology Open, 2019
Spheroids resemble features of tissues and serve as model systems to study cell–cell and cell–ECM interactions in non-adhesive three-dimensional environments.
I. Smyrek, B. Mathew, S. C. Fischer, S. M. Lissek, S. Becker, E. H. K. Stelzer   +5 more
doaj   +1 more source

Three-Dimensional Human Neural Cell Culture Using Tailored Porous Polymer Scaffolds

, 2019
The culture of cells in flat, stiff, two-dimensional environments often results in cells dissimilar to those found in the human body. This can be detrimental in the translation of research outcomes from dish to human, and is particularly evident in the ...
ASHLEY RYAN MURPHY (6373568)
core   +1 more source

Three-dimensional culture may promote cell reprogramming [PDF]

Organogenesis, 2013
Stem cells reside in stem cells niches, which maintain the balance of self-renewal and differentiation of stem cells. In stem cell niches, cell-cell, cell-extracellular matrix interactions and diffusible signals are important elements. However, another pivotal element is that localized and diffusible signals are all organized as three-dimensional (3-D)
Jin, Han, Lei, Chen, Guanzheng, Luo, Bin, Dai, Xiujie, Wang, Jianwu, Dai   +5 more
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source