Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Comparison of survival, acute toxicities, and dose-volume parameters between intensity-modulated radiotherapy with or without internal target volume delineation method and three-dimensional conformal radiotherapy in cervical cancer patients: A retrospective and propensity score-matched analysis. [PDF]
Liang YQ +8 more
europepmc +1 more source
Volumetric Modulated Arc Therapy for lung cancer: Correlation between dose and volume
Abstract Background In lung cancer radiotherapy, the volume of the lung receiving a dose above 20 Gy (V20Gy) and the mean lung dose are widely recognized dosimetric indicators for predicting radiation pneumonitis. However, there is currently no unified model to predict the minimum achievable values of V20Gy and mean lung dose.
Yu Wang +4 more
wiley +1 more source
Abstract Background An accurate assessment of the radiotherapy plans requires an accurate dose to the target and efficient confinement of the doses. However, present indices do not completely cover these aspects in a single framework. Purpose To develop a unified, dimensionless metric that integrates geometric conformity and dosimetric efficiency for ...
Nabaa Mohammed Alsiraj +5 more
wiley +1 more source
Abstract Background RapidArc Dynamic (RAD; Varian Medical Systems, Palo Alto, CA) is a novel volumetric modulated arc therapy (VMAT) technique that features dynamic collimator rotation synchronized with gantry rotation. RAD enables the use of static angle‐modulated ports (STAMPs) defined by user selected gantry and collimator angles.
Hideaki Hirashima +5 more
wiley +1 more source
Publisher Correction: Radiation-induced acute injury of intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy in induction chemotherapy followed by concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: a prospective cohort study. [PDF]
Yao Z, Zhang B, Huang J, Shi L, Cheng B.
europepmc +1 more source
Abstract Background Current Lattice radiation therapy (LRT) mainly uses inverse IMRT/VMAT optimization, which is time‐consuming and complex; however the high modulation complexity compromises dosimetric accuracy and blurs the peak‑to‑valley dose ratio.
Haixia Cui +4 more
wiley +1 more source
Breast size and dose to cardiac substructures in adjuvant three-dimensional conformal radiotherapy compared to tangential intensity modulated radiotherapy. [PDF]
Ratosa I +4 more
europepmc +1 more source
Abstract Background Testicular shielding has long been used to reduce testicular dose during radiation treatment. However, quantitative evaluations of the effectiveness of such shielding in the literature vary substantially. Purpose In this study, the dose reduction expected at both the testicular skin surface and the inside of the testes was evaluated
Joseph Speth +8 more
wiley +1 more source
Treatment of Optic Nerve Sheath Meningioma with Three-Dimensional Conformal Radiotherapy
The treatment of optic nerve sheath meningioma is controversial, but includes observation, radiation therapy, and surgery. Conformal three-dimensional radiotherapy is a technique that allows delivery of radiation to a precise tumor shape and density ...
Karl C. Golnik, MD; A. Lee, MD; S. Woo, MD; P. Moyer
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