Results 131 to 140 of about 12,593,924 (215)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, Volume 20, Issue 10, Page 2410-2423, October 2026.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Volumetric Modulated Arc Therapy for lung cancer: Correlation between dose and volume

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background In lung cancer radiotherapy, the volume of the lung receiving a dose above 20 Gy (V20Gy) and the mean lung dose are widely recognized dosimetric indicators for predicting radiation pneumonitis. However, there is currently no unified model to predict the minimum achievable values of V20Gy and mean lung dose.
Yu Wang   +4 more
wiley   +1 more source

Introducing a novel prediction index for treatment quality of gamma knife and stereotactic‐based radiotherapy: Nabaa Efficiency Index (ηNabaa$\eta^{{\mathrm{Nabaa}}}$)

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background An accurate assessment of the radiotherapy plans requires an accurate dose to the target and efficient confinement of the doses. However, present indices do not completely cover these aspects in a single framework. Purpose To develop a unified, dimensionless metric that integrates geometric conformity and dosimetric efficiency for ...
Nabaa Mohammed Alsiraj   +5 more
wiley   +1 more source

Automated decision support tool for static angle modulated ports configuration in VMAT with dynamic collimator rotation for head and neck cancer

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background RapidArc Dynamic (RAD; Varian Medical Systems, Palo Alto, CA) is a novel volumetric modulated arc therapy (VMAT) technique that features dynamic collimator rotation synchronized with gantry rotation. RAD enables the use of static angle‐modulated ports (STAMPs) defined by user selected gantry and collimator angles.
Hideaki Hirashima   +5 more
wiley   +1 more source

Feasibility of lattice radiation therapy using a noncoplanar vertex arrangement and dynamic conformal arcs

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Current Lattice radiation therapy (LRT) mainly uses inverse IMRT/VMAT optimization, which is time‐consuming and complex; however the high modulation complexity compromises dosimetric accuracy and blurs the peak‑to‑valley dose ratio.
Haixia Cui   +4 more
wiley   +1 more source

Evaluation of testicular shielding effectiveness for surface and internal photon dose using a 3D‐printed scrotal phantom

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Testicular shielding has long been used to reduce testicular dose during radiation treatment. However, quantitative evaluations of the effectiveness of such shielding in the literature vary substantially. Purpose In this study, the dose reduction expected at both the testicular skin surface and the inside of the testes was evaluated
Joseph Speth   +8 more
wiley   +1 more source

Treatment of Optic Nerve Sheath Meningioma with Three-Dimensional Conformal Radiotherapy

open access: yes, 1998
The treatment of optic nerve sheath meningioma is controversial, but includes observation, radiation therapy, and surgery. Conformal three-dimensional radiotherapy is a technique that allows delivery of radiation to a precise tumor shape and density ...
Karl C. Golnik, MD; A. Lee, MD; S. Woo, MD; P. Moyer
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