Results 41 to 50 of about 21,021 (266)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Evaluation of Fatigue Crack Front Shape for a Specimen with Finite Thickness
MATEC Web of Conferences, 2015 Two-dimensional elastic or elasto-plastic models dominate the current fatigue crack growth assessment and life prediction procedures for plate components with through-the-thickness cracks.
He Zhuang +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Three Dimensional Analysis Of Non-Planar Crack Propagation Problems
Gazi Üniversitesi Fen Bilimleri Dergisi, 2017 Energy, defence, aeronautics and space technologies are critical for countries and they are the leading areas which promote and require development of science and technology.
Oğuzhan DEMİR, Ali Osman AYHAN
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Jixie qiangdu, 2019 In this article, three dimensional elastic-plastic curved crack tip opening displacement under quasi-static loads has been mainly studied, and three dimensional curved crack tip opening displacement has been calculated as a practical application of a ...
YANG DaPeng +4 more
doaj
Calculation and Analysis of Crack Stress Intensity Factor and
Jixie chuandong, 2020 The distribution of stress intensity factor and J integral of helical gear with three-dimensional crack under different initial crack parameters is studied. The finite element software is used to analyze the helical gear with initial crack.
Guangyao Sun +2 more
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Machines, 2022 Dynamic modeling and analysis are generally regarded as effective tools to investigate the vibration characteristics and fault mechanisms of planetary gear systems with a tooth crack fault.
Yi Yang +4 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Jixie qiangdu, 2018 In this article,three dimensional elastic-plastic curved crack tip plasticity area under quasi-static loads has been mainly studied,and three dimensional curved crack tip plasticity area has been calculated as a practical application of a second order ...
YANG DaPeng +3 more
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