Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Large-Scale Simulation of Full Three-Dimensional Flow and Combustion of an Aero-Turbofan Engine on Sunway TaihuLight Supercomputer. [PDF]
Entropy (Basel), 2023 Xu Q +6 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown +6 more
wiley +1 more source
Three-Dimensional Numerical Modeling of Macrosegregation in Continuously Cast Billets
Metals, 2017 Macrosegregation, serving as a major defect in billets, can severely degrade material homogeneity. Better understanding of the physical characteristics of macrosegregation through numerical simulation could significantly contribute to the segregation ...
Qipeng Dong +3 more
doaj +1 more source
A three-dimensional flow model of screen channel liquid acquisition devices for propellant management in microgravity. [PDF]
NPJ Microgravity, 2022 Wang Z +6 more
europepmc +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Numerical analysis of Casson nanofluid three-dimensional flow over a rotating frame exposed to a prescribed heat flux with viscous heating. [PDF]
Sci Rep, 2022 Al-Kouz W, Owhaib W.
europepmc +1 more source
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Applications of the contravariant form of the Navier-Stokes equations [PDF]
The contravariant Navier-Stokes equations in weak conservation form are well suited to certain fluid flow analysis problems. Three dimensional contravariant momentum equations may be used to obtain Navier-Stokes equations in weak conservation form on a ...
Katsanis, T.
core +1 more source
Three-Dimensional Flow Analysis of Peristaltic Flow.
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B, 1998 A peristaltic flow is solved by finite difference method. The flow in peristaltic pump is three-dimensionally by the effect of the side walls. Since the actual peristaltic flow has a secondary flow in its cross section against the streamwise direction, so the three-dimensional flow analysis should be employed.
Yonghua CHENG +4 more
openaire +2 more sources