Results 31 to 40 of about 28,932 (246)

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Pseudospectral-Based Rapid Trajectory Planning and Feedforward Linearization Guidance

Drones
A trajectory-based guidance strategy is proposed for the three-dimensional terminal return task of an uncrewed space vehicle (USV). The overall guidance scheme consists of reference trajectory planning and robust trajectory tracking modules.
Lingxia Mu, Shaowei Cao, Ban Wang, Youmin Zhang, Nan Feng, Xiao Li   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Realizing collision avoidance motion for link mechanism using nonlinear model predictive control

Nihon Kikai Gakkai ronbunshu, 2022
In this paper, we aim to develop a technology that can be commonly used for link mechanisms. We use nonlinear model predictive control to design a control system that enables trajectory generation and trajectory tracking using only a single controller ...
Ryu NARIKAWA, Shinji ISHIHARA, Akira KANAZAWA   +2 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Enhancing small object detection for HCI: BRA-YOLO algorithm with RealSense 3D trajectory tracking

Franklin Open
Traditional human–computer interaction (HCI) methods often face limitations in navigating three-dimensional spaces and depth perception, often limited by their two dimensional nature and depth perception challenges.
Xin Ji, Mengkui Wang, Wentong Wang, Qiang Liu   +3 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Gaze-Assisted Prescribed Performance Controller for AUV Trajectory Tracking in Time-Varying Currents

Journal of Marine Science and Engineering
Trajectory tracking for underactuated autonomous underwater vehicles (AUVs) is challenging due to coupling dynamics, modeling inaccuracies, and unknown disturbances. To tackle this, we propose a decoupling gaze-assisted prescribed performance controller (
Zhuoyu Zhang, Mingwei Lin, Dejun Li, Ri Lin   +3 more
doaj   +1 more source

Vision‐based trajectory tracking for mobile robots using Mirage pose estimation method

IET Computer Vision, 2016
Unmanned vehicles are autonomous robotic systems that are fully or partially controlled by an operator remotely from a station. In the last two decades, massive amount of advancements have been observed regarding unmanned vehicles for both military and ...
Semih Dinc, Farbod Fahimi, Ramazan Aygun
doaj   +1 more source