Results 91 to 100 of about 326,091 (194)

Contrasting effects of glutamate and branched-chain amino acid metabolism on acid tolerance in a <i>Castellaniella</i> isolate from acidic groundwater. [PDF]

Appl Environ Microbiol
Goff JL, Durrence KL, Thorgersen MP, Trotter VV, Chen Y, Kosina SM, Wang ALW, Poole FL, Northen TR, Petzold CJ, Deutschbauer AM, Adams MWW.   +11 more
europepmc   +1 more source

Threonine Biosynthesis

Journal of Biological Chemistry, 1965
Marshall M. Kaplan, Martin Flavin
openaire   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

A metabolomics study reveals potential plasma biomarkers for predicting post-infarction left ventricular remodeling: findings from the metabolights database. [PDF]

Front Cardiovasc Med
Chen D, Wu Y, Xie Z, Li J, Luo S, Xu S.
europepmc   +1 more source

Oxidation and allocation of nectar amino acids during butterfly flight. [PDF]

J Exp Biol
Tigreros N, Davidowitz G, Burkholder C, Chabaud C.   +3 more
europepmc   +1 more source

Liganden der Lipidtasche induzieren allosterische Modulation der Proteindynamik im Bereich des aktiven Zentrums der Proteinkinase p38α

Angewandte Chemie, EarlyView.
Bei der Suche nach neuen allosterischen Stellen in der Serin/Threonin‐Kinase p38α deckt die NMR‐Spektroskopie eine dynamische Kopplung zwischen dem katalytischen Zentrum und der Lipidtasche auf. Die Ergebnisse offenbaren bewegungsbezogene Interdependenzen, die entfernte Regionen des Enzyms miteinander verbinden, was die Lipidtasche als ...
Sara Medina Gómez, Laurin T. Homberg, Mike Bührmann, Daniel Rauh, Rasmus Linser   +4 more
wiley   +1 more source

KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury. [PDF]

Front Mol Neurosci
Liabeuf S, Brocard C, Coq JO, Vinay L, Brocard F.   +4 more
europepmc   +1 more source

Urea cycle modulation by combined SGLT2 inhibitors and metformin. [PDF]

BMC Med
Harada M, Adam J, Han S, Shi M, Ge J, Lintelmann J, Cecil A, Zukunft S, Prehn C, Witting M, Scheerer MF, Neschen S, Irmler M, Beckers J, Adamski J, Teupser D, Linkohr B, Gieger C, de Angelis MH, Peters A, Wang-Sattler R.   +20 more
europepmc   +1 more source

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α

Angewandte Chemie International Edition, EarlyView.
Used in search of novel allosteric sites in the serine/threonine kinase p38α, NMR spectroscopy reveals a dynamic coupling between the catalytic and lipid pockets. The findings uncover a motional interdependence that links distant regions of the enzyme, highlighting the lipid pocket as a promising site for allosteric intervention.
Sara Medina Gómez, Laurin T. Homberg, Mike Bührmann, Daniel Rauh, Rasmus Linser   +4 more
wiley   +1 more source

XIAP down-regulation inhibits RIPK2 ubiquitination-mediated insulin resistance. [PDF]

Endocr Connect
Zhao C, Zhang Z, Li R, Geng X.
europepmc   +1 more source