Results 111 to 120 of about 52,600 (247)

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Free radical destruction of hydroxyl-containing amino acids

Журнал Белорусского государственного университета: Химия, 2019
А new way of the free radical ROS- and HOCl-induced destruction of serine, threonine, and their peptide derivatives due to the nitrogen-centered radicals formation and their subsequent decomposition with the side chain elimination has been established ...
Anastasia A. Sladkova, Irina P. Edimecheva, Anna A. Sosnovskaya, Oleg I. Shadyro   +3 more
doaj   +1 more source

Efficiency of threonine utilization in the growing pigs

, 2016
Objective. This study aimed to determine the marginal efficiency of threonine utilization in growing pigs by using the nitrogen balance technique. Materials and methods.
Alves, Débora A., T Rocha, Leonardo, de Quadros, Arlei B., Rocha, Leonardo T., Gewehr, Clóvis Eliseu, A Alves, Débora, E Gewehr, Clóvis, Ceron, Marcos S., B de Quadros, Arlei, de Oliveira, Vladimir, S Ceron, Marcos   +10 more
core   +3 more sources

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Effects of Dietary Threonine Levels on Growth Performance, Biochemical Parameters, Muscle Quality, and Intestinal Microflora of Rice Field Eel (Monopterus albus)

Animals
To evaluate the effects of dietary threonine levels on rice field eels (Monopterus albus), six experimental diets were formulated with graded threonine supplementation: 0 g/kg (T1), 3 g/kg (T2), 6 g/kg (T3), 9 g/kg (T4), 12 g/kg (T5), and 15 g/kg (T6 ...
Denghang Yu, Yujia Liu, Jiaxiang Chen, Jincheng Wan, Jiaqi Zhang, Chi Zhang   +5 more
doaj   +1 more source

Threonine Requirement of the Grower Turkey Tom

, 2008
Two experiments were conducted to determine threonine requirement for maximum performance and breast and drumstick major muscle relative weights of turkey toms raised from 8-10wk and 11-13wk of age.
Mohamad T. Farran, George W. Barbour, Michael S. Lilburn   +2 more
core   +1 more source

Characterization of an Arabidopsis thaliana cDNA encoding an S-adenosylmethionine-sensitive threonine synthase Threonine synthase from higher plants [PDF]

, 1996
An Arabidopsis thaliana cDNA encoding an Sadenosylmethionine-sensitive threonine synthase (EC 4.2.99.2) has been isolated by functional complementation of an Escherichia coli mutant devoid of threonine synthase activity.
Gilles Curien, Curien, Gilles, Renaud Dumas, Ravanel, Stéphane, Dumas, Renaud, Stéphane Ravanel, Roland Douce, Douce, Roland   +7 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

(4-L-THREONINE)-OXYTOCIN

, 1970
A novel biologically active (4-L-threonine)-oxytocin which is an analog of oxytocin in which the glutamine residue in position four is replaced by a threonine ...
Manning, Maurice
core  

The threonine requirement for reproduction in swine

, 1982
L-threonine was added to a fortified corn-gelatin diet to attain theonine levels of 3.59, 4.95, 6.31, 7.67 and 9.03 g per day. These diets were fed to twenty-five crossbred gilts at a rate of 1.82 kg per day before mating and during 3 successive ...
Leonard, Robert
core   +1 more source