Results 121 to 130 of about 341,179 (261)

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Threonine and glutamine in ovo supplementation affects post-hatch development and expression of genes related to the first line of defense of the intestinal mucosa in broiler chickens. [PDF]

Poult Sci
Santos WS, Sousa AV, Gomes DS, Marinho GF, Oliveria TJ, Givisiez PEN, Oliveira CJB, Malheiros RD, Filho ALBM.   +8 more
europepmc   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Lactobacillus Is Associated With Disease in Pulmonary Arterial Hypertension: A Prospective Cohort Study. [PDF]

Compr Physiol
Jose A, Apewokin S, Ollberding NJ, Duan Q, Trannguyen J, Prisco SZ, Thenappan T, Hemnes AR, Elwing JM.   +8 more
europepmc   +1 more source

Spectrum of Congenital Anomalies in Myhre Syndrome—Insights Into Effects Brought by Altered TGF‐β Signaling via Gain‐of‐Function Variants in SMAD4

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is a rare genetic disorder characterized by progressive multisystem involvement. Gain‐of‐function missense heterozygous variants affecting the Ile500 residue and Arg496 residue of the SMAD4 gene are implicated in this condition.
Kawmadi Gunawardena, Alessandro De Falco, Deborah Osio, Eleanor Sherlock, Emma Kivuva, Erina Sasaki, Francis H. Sansbury, Nayana Lahiri, Patricia Foley, Sahar Mansour, Shane McKee, Tazeen Ashraf, Nicola Brunetti‐Pierri, Usha Kini   +13 more
wiley   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Detecting amyloid-β pathology in subjective cognitive decline using plasma and CSF biomarkers. [PDF]

EBioMedicine
Contador J, Pozzi FE, Sánchez-Benavides G, Fernández-Arcos A, Lantero-Rodríguez J, Montoliu-Gaya L, Minguillon C, Fauria K, González-Escalante A, Ortiz-Romero P, Blasco-Forniés H, de Diego-Osaba M, Jiménez Moyano E, Quijano-Rubio C, Kollmorgen G, Le Bastard N, Nadal A, Vanmechelen E, Jeromin A, Torres-Torronteras J, Ashton NJ, Zetterberg H, Blennow K, Gispert JD, Molinuevo JL, Del Campo M, Grau-Rivera O, Suárez-Calvet M, β-AARC Study collaborators.   +28 more
europepmc   +1 more source

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

New Water Oxidation Mechanism in Photosystem II Resolves Major Experimental Controversies

Angewandte Chemie, EarlyView.
In Photosystem II Oxygen Evolving Complex, we discovered the O3‐O6 peroxide at lower energy. Assignment of the O3 ligated by histidine (His337) as a slow exchanging substrate and its coupling with O6 give the O─O bond formation mechanism most consistent with all currently available experimental data. Proposal shows how protein environment can steer the
Yulia Pushkar
wiley   +2 more sources

Enhanced strand transfer and mismatch extension by HIV-1C reverse transcriptase promote sequence motif duplication. [PDF]

J Virol
Panchapakesan A, Joshi AP, Amanullah A, Pargain N, Mehta K, Shanmugam M, Singh J, Saini C, Nala N, Ramagopal UA, Ranga U.   +10 more
europepmc   +1 more source