Results 111 to 120 of about 604,484 (380)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]

, 2015
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R, Arnold, Don B, Langen, Ralf, Lewis, Yuka E, Lin, Yu Hsuan, Marotta, Nicholas P, Pratt, Matthew R, Roth, Maxwell T, Zaro, Balyn W   +8 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Effects of different dietary threonine and glycine supplies in broilers fed low-protein diets

Frontiers in Veterinary Science
The reduction of crude protein (CP) content of broiler diets with balanced amino acid supply can increase the nitrogen (N) utilization efficiency and reduce ammonia emission, the risk of many health problems in birds.
Patrik Strifler, Boglárka Horváth, Nikoletta Such, Károly Dublecz, László Pál   +4 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Bioavailability of threonine and tryptophan in peanut meal for starter pigs using slope-ratio assay

Animal, 2009
The objective of the two studies was to determine the bioavailability of threonine (thr) and tryptophan (trp) in peanut meal, relative to l-thr and l-trp, for starter pigs using the slope-ratio bioassay. Basal diets (BDs) contained surfeit amounts of all
O. Adeola
doaj   +1 more source

Growth performance, jejunum morphology and mucin-2 gene expression of broiler Japanese quails fed low-protein diets supplemented with threonine

Italian Journal of Animal Science, 2020
The present experiment was conducted to examine the effects of threonine supplementation in low-protein diets on growth performance, jejunum morphology, and mucin-2 gene expression in meat-type Japanese quails. A total of 800 broiler quails were assigned
Ashkan Emadinia, Majid Toghyani, Amir Davar Foroozandeh, Sayed Ali Tabeidian, Maryam Ostadsharif   +4 more
doaj   +1 more source

Phospho.ELM:a database of experimentally verified phosphorylation sites in eukaryotic proteins [PDF]

, 2004
BACKGROUND: Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes.
Blom, Nikolaj, Cameron, Scott, Diella, Francesca, Gemünd, Christine, Gibson, Toby J., Kuster, Bernhard, Linding, Rune, Sicheritz-Pontén, Thomas, Via, Allegra   +8 more
core   +4 more sources

Metabolism of Threonine by Penicillia: Growth on Threonine as the Sole Carbon and Nitrogen Source [PDF]

Journal of General Microbiology, 1972
SUMMARY: Two species of Penicillium were isolated from soil by their ability to grow aerobically on L-threonine as sole source of energy and cellular carbon and nitrogen. Threonine-grown fungi contained a highly active inducible L-threonine: NAD+ dehydrogenase and a significantly less active constitutive ‘biosynthetic' threonine dehydratase, but ...
openaire   +3 more sources