Results 141 to 150 of about 548,221 (334)
Free amino acids in a cave beetle \u3cem\u3eDarlingtonea kentuckensis\u3c/em\u3e Valentine (Coleoptera: Carabidae) [PDF]
, 1974 Free amino acids of Darlingtonea kentuckensis were investigated by two-dimensional, thin-layer chromatography on Silica Gel G. Thirteen amino acids which could be identifìed (alanine, glutamic acid, glycine, histidine, isoleucine and/or leucine, lysine ...
Sperka, R. J.
core +2 more sources
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
The Effect of Branched Chain Amino Acids on the Synthesis of Isoleucine from Threonine and Pyruvate in Crude Extracts from Escherichia coli. [PDF]
, 1970 Raimo Raunio +4 more
openalex +1 more source
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
Advanced Science, EarlyView.SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
STUDIES ON THE MECHANISM OF DEAMINATION OF SERINE AND THREONINE IN BIOLOGICAL SYSTEMS
, 1943 Erwin Chargaff, David B. Sprinson
openalex +1 more source
Advanced Science, EarlyView.Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li +8 more
wiley +1 more source
Threonine in different phenotypes of chronic heart failure with preserved ejection fraction
Russian Open Medical JournalBackground — Chronic heart failure with preserved ejection fraction (CHFpEF) develops as a result of many diseases that lead to significant metabolic disorders.
Maria F. Petruhnova +10 more
doaj +1 more source
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source