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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family. [PDF]
BackgroundIt is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to mitigate such metabolite damage.
Cooper, Arthur JL +8 more
core +2 more sources
Growth performance and small intestinal morphology of native chickens after feed supplementation with tryptophan and threonine during the starter phase [PDF]
Background and Aim: The amino acid content of feed can affect growth performance of poultry during the first 6 weeks of life or the starter phase.
Charles V. Lisnahan, Oktovianus R. Nahak
doaj +1 more source
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Two experiments were conducted to evaluate growth performance, immune responses and carcass traits of CARIBRO Vishal broilers fed dietary L-Thr in low protein diets without or with the balance of Lys and Met.
Joel O Alabi +8 more
doaj
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
A 42-day feeding trial was carried out to evaluate the effect of dietary supplementation of zinc and threonine on the integrity of intestinal mucosa and expression of intestinal mucin 5ac (MUC5AC) gene in broiler chickens.
Justin Adébayo Hounkpêvi +4 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Phospho.ELM:a database of experimentally verified phosphorylation sites in eukaryotic proteins [PDF]
BACKGROUND: Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes.
Blom, Nikolaj +8 more
core +4 more sources
Para determinar el efecto de la adición de Ractopamina (RAC) y la relación Treonina:Lisina (Thr:Lys) sobre los rendimientos productivos, se realizó un experimento durante 28 días.
Jaime Eduardo Parra Suescún +1 more
doaj

