Results 91 to 100 of about 919,157 (297)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Opinion piece: A call to unite in a common cause

Journal of Learning Development in Higher Education, 2009
This opinion piece argues that despite the successes of the Learning Development network, and the learning development community, separate development of this community may also have some dangers.
Chris Rust
doaj   +1 more source

Operationalising a Threshold Concept in Economics: A Pilot Study Using Multiple Choice Questions on Opportunity Cost [PDF]

This paper addresses the emerging educational framework that envisions threshold concepts as mediators of learning outcomes. While the threshold concepts framework is highly appealing on a theoretical level, few researchers have attempted to measure ...
Gigi Foster, Jan H. F. Meyer, Martin P. Shanahan   +2 more
core  

Cracking in asphalt materials [PDF]

, 2018
This chapter provides a comprehensive review of both laboratory characterization and modelling of bulk material fracture in asphalt mixtures. For the purpose of organization, this chapter is divided into a section on laboratory tests and a section on ...
AF Braham, Armelle Chabot, B Behnia, B Birgisson, B Delaporte, B Kim, BS Underwood, C Huet, D Bodin, D Bodin, Didier Bodin, DV Ramsamooj, Emmanuel Chailleux, Eshan V. Dave, Eshan V. Dave, Eshan V. Dave, F Dubois, F Dubois, F Dubois, F Jiang, GR Chehab, H Benedetto Di, H Benedetto Di, H Lemaistre, HJ Lee, HM Nguyen, J Mandel, JF Corte, JS Daniel, K Majidzadeh, Malcolm L. Williams, MJ Jacobs, MJ Lamborn, MP Wagoner, MP Wagoner, N Tapsoba, NH Gibson, R Roque, R Roque, R. A. Schapery, RA Schapery, RA Schapery, RA Schapery, S Ahmed, S Ahmed, S Ahmed, SH Song, Simon Pouget, SW Park, T Hou, Xinjun Li, YR Kim, YR Kim, YR Kim, YR Kim, Z Zhang, Z Zhang   +56 more
core   +5 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Intersections between Law and Language: Disciplinary Concepts in Second Language Legal Literacy

Studies in Logic, Grammar and Rhetoric, 2016
International mobility among graduate students of law presents unique challenges for the teaching and learning of Legal English. Master of Laws (LL.M.) students, for example, often bring both prior legal training and professional experience from their ...
Hartig Alissa J.
doaj   +1 more source

Spin-Glass Theory for Pedestrians

, 2005
In these notes the main theoretical concepts and techniques in the field of mean-field spin-glasses are reviewed in a compact and pedagogical way, for the benefit of the graduate and undergraduate student. One particular spin-glass model is analyzed (the
Andrea Cavagna, Barrat A, Bender C M, Bengtzelius U, Binney J J, Biroli G, Bray A J, Cardy J, Cavagna A, Cavagna A, Cavagna A, Cugliandolo L, De Almeida J R L, De Dominicis C, De Dominicis C, De Gaulle C, Edwards S F, Franz S, Gardiner C W, Götze W, Hertz J, Kurchan J, Kurchan J, Martin C P, Mézard M, Mézard M, Parisi G, Parisi G, Parisi G, Reichman D, Ruelle D, Sciortino F, Thirumalai D, Thouless D J, Tommaso Castellani, Zinn-Justin J, Zwanzig R   +36 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source