Results 101 to 110 of about 919,157 (297)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dopaminergic Regulation of Neuronal Circuits in Prefrontal Cortex [PDF]
, 2001 Neuromodulators, like dopamine, have considerable influence on the\ud processing capabilities of neural networks. \ud This has for instance been shown in the working memory functions\ud of prefrontal cortex, which may be regulated by altering the\ud ...
Scheler, Gabriele
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
JuxtaLearn DELIVERABLE Report D3.5 Service scenario documentation [PDF]
, 2016 The purpose of Deliverable 3.5 is to provide guidelines to creating juxtaposed performance, particularly to advise non-drama teachers on what to do and how to manage performance in stage 3 of the JuxtaLearn process.
Adams, Anne, Hartnett, Elizabeth
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effectiveness of Flipped Classroom Strategies on Learning Outcomes in Economics Threshold Concepts Across Arts, Commerce, and Science Disciplines in Secondary Schools [PDF]
International Journal of Advanced Humanities ResearchThe effectiveness of flipped classroom learning on learning outcomes in economics threshold concepts across three disciplines, namely arts, commerce, and science, in secondary schools in Nigeria was explored through a quasi-experimental design using a ...
Abidat Mohammed +2 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
'Multisensory Holistic Immersion': The Method of Insider Inquiry Skills as a Threshold Concept
Journal of Learning Development in Higher Education, 2013 Insider inquiry involves being immersed in local situations and generating contextually embedded knowledge which emerges from direct experience. Insider inquiry requires a method that facilitates attending to observable data, envisaging possible ...
David Coghlan, Anne Graham Cagney
doaj +1 more source
Threshold concepts in medical education: A scoping review. [PDF]
Med Educ, 2022 Jones H, Hammond L.
europepmc +1 more source
Top quark mass definition and top quark pair production near threshold at the NLC
, 2001 We suggest an infrared-insensitive quark mass, defined by subtracting the soft part of the quark self energy from the pole mass. We demonstrate the deep relation of this definition with the static quark-antiquark potential.
A. Billoire +57 more
core +1 more source