Results 111 to 120 of about 918,204 (297)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Threshold concepts in health professions education research: a scoping review. [PDF]

Adv Health Sci Educ Theory Pract, 2022
Liljedahl M, Palmgren PJ, McGrath C.
europepmc   +1 more source

Inviting students to determine for themselves what it means to write across the disciplines [PDF]

, 2016
Situated in the literature on threshold concepts and transfer of prior knowledge in WAC/WID and composition studies, with particular emphasis on the scholarship of writing across difference, our article explores the possibility of re-envisioning the role
Garcia de Mueller, Genevieve, Hendrickson, Brian   +1 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Threshold Concepts in Preclinical Medical Education: Students' Perceptions. [PDF]

Med Sci Educ, 2021
Derias N, Loftus S, Kamel-ElSayed S.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Sustainability: Teaching an Interdisciplinary Threshold Concept through Traditional Lecture and Active Learning

Canadian Journal for the Scholarship of Teaching and Learning, 2015
One of the difficulties in teaching global sustainability in the introductory political science classes is the different emphases placed on this concept and the absence of the consensus on where the overall balance between environmental protection ...
Ekaterina M. Levintova, Daniel W. Mueller   +1 more
doaj  

Identification of histological threshold concepts in health sciences curricula: Students' perception. [PDF]

Anat Sci Educ, 2023
Martin-Piedra MA, Saavedra-Casado S, Santisteban-Espejo A, Campos F, Chato-Astrain J, Garcia-Garcia OD, Sanchez-Porras D, Luna Del Castillo JD, Rodriguez IA, Campos A.   +9 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Identifying threshold concepts in postgraduate general practice training: a focus group, qualitative study. [PDF]

BMJ Open, 2022
Hall K, Chae A.
europepmc   +1 more source