Results 81 to 90 of about 918,204 (297)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Mapping Digital Literacy Thresholds in South African Higher Education and the Implications for Entrepreneurship Education in an Industry 4.0 Paradigm

Administrative Sciences
This study investigates digital literacy thresholds within South African higher education institutions in the context of Industry 4.0, focusing on entrepreneurship education.
Fidel Isheanesu Mugunzva, Ntise Hendrick Manchidi   +1 more
doaj   +1 more source

Exploring threshold concepts in population health [PDF]

The Clinical Teacher, 2019
Summary Background Doctors are increasingly expected to improve the health and well‐being of populations, as well as to care for individuals. However, despite extensive efforts to integrate population health into undergraduate programmes, engaging students in such learning is notoriously ...
Hilary Neve, Eleanor J Hothersall, Veena Rodrigues   +2 more
openaire   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

What Are US Undergraduates Taught and What Have They Learned About US Continental Crust and Its Sedimentary Basins?

Geosciences
We need to educate students and the public about addressing natural resource challenges to maintain civilization moving into a sustainable future.
Clinton Whitaker Crowley, Robert James Stern   +1 more
doaj   +1 more source

Moments of clarity : a study of higher education teachers' professional learning experiences and the transformational process of change in self-efficacy development : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Education at Massey University, Manawatū, New Zealand [PDF]

, 2017
This qualitative longitudinal study sought to understand ‘aha’ moments experienced by a group of early career higher education teachers in Aotearoa New Zealand and the role those moments played in the transformational process of change in teacher self ...
Percy, Bridget Marie
core  

Cracking in asphalt materials [PDF]

, 2018
This chapter provides a comprehensive review of both laboratory characterization and modelling of bulk material fracture in asphalt mixtures. For the purpose of organization, this chapter is divided into a section on laboratory tests and a section on ...
AF Braham, Armelle Chabot, B Behnia, B Birgisson, B Delaporte, B Kim, BS Underwood, C Huet, D Bodin, D Bodin, Didier Bodin, DV Ramsamooj, Emmanuel Chailleux, Eshan V. Dave, Eshan V. Dave, Eshan V. Dave, F Dubois, F Dubois, F Dubois, F Jiang, GR Chehab, H Benedetto Di, H Benedetto Di, H Lemaistre, HJ Lee, HM Nguyen, J Mandel, JF Corte, JS Daniel, K Majidzadeh, Malcolm L. Williams, MJ Jacobs, MJ Lamborn, MP Wagoner, MP Wagoner, N Tapsoba, NH Gibson, R Roque, R Roque, R. A. Schapery, RA Schapery, RA Schapery, RA Schapery, S Ahmed, S Ahmed, S Ahmed, SH Song, Simon Pouget, SW Park, T Hou, Xinjun Li, YR Kim, YR Kim, YR Kim, YR Kim, Z Zhang, Z Zhang   +56 more
core   +5 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Reddit as an Analogy for Scholarly Publishing and the Constructed, Contextual Nature of Authority

Communications in Information Literacy, 2019
This paper provides an overview of how the social news site Reddit can be used as an example of the ACRL Framework for Information Literacy for Higher Education threshold concept “Authority is Constructed and Contextual.” It posits that the construction ...
Anna M White
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source