A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Administrative SciencesThis study investigates digital literacy thresholds within South African higher education institutions in the context of Industry 4.0, focusing on entrepreneurship education.
Fidel Isheanesu Mugunzva +1 more
doaj +1 more source
Exploring threshold concepts in population health [PDF]
The Clinical Teacher, 2019 Summary Background Doctors are increasingly expected to improve the health and well‐being of populations, as well as to care for individuals. However, despite extensive efforts to integrate population health into undergraduate programmes, engaging students in such learning is notoriously ...
Hilary Neve +2 more
openaire +4 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
GeosciencesWe need to educate students and the public about addressing natural resource challenges to maintain civilization moving into a sustainable future.
Clinton Whitaker Crowley +1 more
doaj +1 more source
Moments of clarity : a study of higher education teachers' professional learning experiences and the transformational process of change in self-efficacy development : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Education at Massey University, Manawatū, New Zealand [PDF]
, 2017 This qualitative longitudinal study sought to understand ‘aha’ moments experienced by a group of early career higher education teachers in Aotearoa New Zealand and the role those moments played in the transformational process of change in teacher self ...
Percy, Bridget Marie
core
The Internationalisation of UK Higher Education: From ‘technical observance’ to ‘relational participation’, the road to CAPRI… [PDF]
, 2009 This article reflects on a review of the literature on the internationalisation of UK higher education (HE) commissioned by the Higher Education Academy (HEA) in 2006.
Caruana, V
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Reddit as an Analogy for Scholarly Publishing and the Constructed, Contextual Nature of Authority
Communications in Information Literacy, 2019 This paper provides an overview of how the social news site Reddit can be used as an example of the ACRL Framework for Information Literacy for Higher Education threshold concept “Authority is Constructed and Contextual.” It posits that the construction ...
Anna M White
doaj +1 more source
An electronics Threshold-Concept Inventory: Assessment in the face of the dependency of concepts [PDF]
, 2012 The Theory of Threshold Concepts (TCs), first articulated by Land and Meyer in 2003, provides educators in many disciplines with a tool to identify those special ideas that both define the characteristic ways of thinking of expert practitioners, and ...
Harlow, Ann +2 more
core +1 more source