Results 31 to 40 of about 452,379 (303)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Burn threshold prediction for high efficiency deep grinding [PDF]

open access: yes, 2006
Burn threshold diagrams are useful for the prediction of thermally induced grinding damage and were originally developed to describe the conventional shallow cut grinding regime.
A. Bell   +5 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

STUDY OF FORMALDEHYDE CONCENTRATION LEVELS IN THE AIR OF WORK PLACES

open access: yesIranian Journal of Public Health, 1997
In this research, air sampling of workplaces was carried out by two methods (long - time and short - time). The mean formaldehyde concentration with long - time method in pathology labs, surgery and endoscopy sections were 0.96 0.25 and 0.13 ppm and with
M. Ghasemkhani
doaj  

Rest in a Warming Workplace: Resituating the Science and Policy of Non‐Work Under Climate Change

open access: yesGeo: Geography and Environment
Rest is increasingly presented as a key solution to the challenge of rising workplace temperatures under climate change. Yet, despite this growing importance, the scientific literature often treats the relationship between rest and core temperature ...
Pratik Mishra, Laurie Parsons
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Determining Free-Flow Speed on Different Classes of Rural Two-Lane Highways

open access: yesPromet (Zagreb), 2023
Current analytical free-flow speed models consider all rural two-lane highways as the same road type despite their different functional significance in the network.
Nemanja Stepanović   +2 more
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Comparison of occupational exposure limits in China with threshold limit values announced by American Conference of Governmental Industrial Hygienists

open access: yes环境与职业医学
BackgroundThe threshold limit values (TLVs) established and regularly updated by the American Conference of Governmental Industrial Hygienists (ACGIH) are widely adopted and referenced globally, serving as a crucial reference for China's occupational ...
Qiangzhi GUO   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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