Results 61 to 70 of about 3,798,889 (297)

Cross-validatory extreme value threshold selection and uncertainty with application to ocean storm severity

, 2016
Designs conditions for marine structures are typically informed by threshold-based extreme value analyses of oceanographic variables, in which excesses of a high threshold are modelled by a generalized Pareto (GP) distribution.
Attalides, Nicolas, Jonathan, Philip, Northrop, Paul   +2 more
core   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Effect of Urban Greening on Incremental PM2.5 Concentration During Peak Hours

Frontiers in Public Health, 2020
In China, severe haze is a major public health concern affecting residents' health and well-being. This study used hourly air quality monitoring data from 285 cities in China to analyze the effect of green coverage (GC) and other economic variables on ...
Shaogu Wang, Shunqi Cheng, Xinhua Qi
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Neural Field Models with Threshold Noise [PDF]

The Journal of Mathematical Neuroscience, 2016
The original neural field model of Wilson and Cowan is often interpreted as the averaged behaviour of a network of switch like neural elements with a distribution of switch thresholds, giving rise to the classic sigmoidal population firing-rate function so prevalent in large scale neuronal modelling.
Thul, Ruediger, Coombes, Stephen, Laing, Carlo R.   +2 more
openaire   +4 more sources

A damage model based on failure threshold weakening

, 2010
A variety of studies have modeled the physics of material deformation and damage as examples of generalized phase transitions, involving either critical phenomena or spinodal nucleation.
Bak, Ben-Zion, Brown, Burridge, Carlson, Clar, Coniglio, Curtin, Daniels, Dieterich, Donald L. Turcotte, Drossel, Egolf, Ferguson, Gabaix, Garcimartin, Goldenfeld, Grassberger, Hamiel, Herz, Houle, James R. Holliday, John B. Rundle, Joseph D. Gran, Katz, Klein, Klein, Kun, Lyakhovsky, Lyakhovsky, Maes, Main, Malamud, Meinders, Nechad, Newman, Newman, Phoenix, Pierce, Pradhan, Pride, Rundle, Rundle, Rundle, Rundle, Rundle, Serino, Stauffer, Thirumalai, Thirumalai, Tiampo, Turcotte, Virgilii, William Klein, Xia, Zapperi   +55 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

SELF EXCITING THRESHOLD INTEREST RATES MODELS [PDF]

International Journal of Theoretical and Applied Finance, 2005
In this paper, we study a new class of tractable diffusions suitable for model's primitives of interest rates. We consider scalar diffusions with scale s′(x) and speed m(x) densities discontinuous at the level x*. We call that family of processes Self Exciting Threshold (SET) diffusions.
MARC DECAMPS, MARC GOOVAERTS, WIM SCHOUTENS   +2 more
openaire   +3 more sources

Endogeneity in Semiparametric Threshold Regression Model With Two Threshold Variables

SSRN Electronic Journal, 2021
This article considers a semiparametric threshold regression model with two threshold variables. The proposed model allows endogenous threshold variables and endogenous slope regressors. Under the diminishing threshold effects framework, we derive consistency and asymptotic results of our proposed estimator for weakly dependent data.
Chaoyi Chen, Thanasis Stengos, Yiguo Sun
openaire   +1 more source