Results 101 to 110 of about 1,445,591 (343)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
THORS: An Efficient Approach for Making Classifiers Cost-Sensitive
IEEE Access, 2019 In this paper, we propose an effective THresholding method based on the Order Statistic, called THORS, to convert an arbitrary scoring-type classifier, which can induce a continuous cumulative distribution function of the score, into a cost-sensitive one.
Ye Tian, Weiping Zhang
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Positron, 2013 Penelitian ini menentukan nilai thresholding pada citra tulang tangan normal dan osteoporosis. Citra yang digunakan adalah 5 citra tulang tangan normal dan 3 citra tulang tangan osteoporosis.
Wara Mitha Nabella +2 more
doaj +1 more source
, 2017 The paper presents a general formal framework representing the role of balancing of values in interpretation of statutory rules. The model developed here is an extension of the model of teleological interpretation, where a given interpretive outcome is justified if it satisfies a given goal (or a set of goals).
Araszkiewicz, Michał, Żurek, Tomasz
openaire +3 more sources
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Aplikasi Pendeteksi Kelayakan Telur Menggunakan Metode Backpropagation dan Thresholding
J-Intech (Journal of Information and Technology), 2018 Perkembangan teknologi yang semakin maju membuat kebutuhan seseorang dalam hal kecepatan dalam penyelesaian masalah sangat dibutuhkan. Salah satunya yakni untuk mendeteksi kelayakan telur menggunakan pembiasan sinar pada telur (candling).
Harman Tunggorono
doaj
SENSORY THRESHOLDS FOR SOLUTIONS OF PHENYL‐THIO‐CARBAMIDE: RESULTS OF TESTS ON A LARGE SAMPLE, MADE BY R. A. FISHER [PDF]
, 1946 D. S. Falconer
openalex +1 more source