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Nature, 1946
BARRATT1 found in 1932 that bacteria do not cause the decomposition of thrombin preparations, but rather that this is a chemical process I have shown that the inactivation of thrombin in native blood and in the pure thrombin solution is the same process as that which is caused by an inactivating system in plasma, but which in the preparation is present
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BARRATT1 found in 1932 that bacteria do not cause the decomposition of thrombin preparations, but rather that this is a chemical process I have shown that the inactivation of thrombin in native blood and in the pure thrombin solution is the same process as that which is caused by an inactivating system in plasma, but which in the preparation is present
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Chest, 2003
The generation of the enzyme thrombin from its precursor prothrombin is the central event of the blood coagulation process, which is essential to hemostasis and the culprit in thrombosis. Thrombin is produced by a complex series of proteolytic events that are initiated when cryptic tissue factor interacts with plasma factor VIIa to initiate the complex
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The generation of the enzyme thrombin from its precursor prothrombin is the central event of the blood coagulation process, which is essential to hemostasis and the culprit in thrombosis. Thrombin is produced by a complex series of proteolytic events that are initiated when cryptic tissue factor interacts with plasma factor VIIa to initiate the complex
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Thrombosis and Haemostasis, 1995
A model of thrombin interaction with distinct substrates or ligands has been derived from the crystallographic studies of thrombin-inhibitors complexes, and buttressed by functional studies with mutant thrombins, thrombin proteolytic derivatives or antibodies against thrombin.
M C, Guillin +3 more
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A model of thrombin interaction with distinct substrates or ligands has been derived from the crystallographic studies of thrombin-inhibitors complexes, and buttressed by functional studies with mutant thrombins, thrombin proteolytic derivatives or antibodies against thrombin.
M C, Guillin +3 more
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Archives of Biochemistry and Biophysics, 1961
Seegers citrate thrombin was prepared from bovine plasma and purified on IRC-50 (XE-64) resin columns at room temperature. The preparation was examined in the ultracentrifuge to determine the sedimentation coefficient and Archibald molecular weight. All measurements were made at 20 °C.
M A, COHLY, H A, SCHERAGA
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Seegers citrate thrombin was prepared from bovine plasma and purified on IRC-50 (XE-64) resin columns at room temperature. The preparation was examined in the ultracentrifuge to determine the sedimentation coefficient and Archibald molecular weight. All measurements were made at 20 °C.
M A, COHLY, H A, SCHERAGA
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
Thrombin is the final protease generated in the blood coagulation cascade. It has multiple substrates and cofactors, and serves both pro- and anti-coagulant functions. How thrombin activity is directed throughout the evolution of a clot and the role of conformational change in determining thrombin specificity are issues that lie at the heart of the ...
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Thrombin is the final protease generated in the blood coagulation cascade. It has multiple substrates and cofactors, and serves both pro- and anti-coagulant functions. How thrombin activity is directed throughout the evolution of a clot and the role of conformational change in determining thrombin specificity are issues that lie at the heart of the ...
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Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation
Thrombosis and Haemostasis, 1997Thrombin mediates acute vascular thrombosis and subsequent vascular lesion formation following mechanical denuding injury or spontaneous atherosclerotic plaque rupture. In the process of generating thrombin Factor VII/VIIa binds avidly with tissue factor (TF) exposed on cellular membranes, and coagulation serine proteases are sequentially cleaved via ...
L A, Harker, S R, Hanson, A B, Kelly
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Seminars in Thrombosis and Hemostasis, 1998
From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombosis, coronary thrombosis, stroke ...
J W, Fenton +3 more
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From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombosis, coronary thrombosis, stroke ...
J W, Fenton +3 more
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Chest, 2003
When the activities of the coagulation and fibrinolytic cascades are properly regulated, so that fibrin (FN) deposition and removal are properly balanced, the vascular system is protected from catastrophic blood loss at the site of an injury, while its fluidity is ensured elsewhere.
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When the activities of the coagulation and fibrinolytic cascades are properly regulated, so that fibrin (FN) deposition and removal are properly balanced, the vascular system is protected from catastrophic blood loss at the site of an injury, while its fluidity is ensured elsewhere.
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2011
Thrombosis is the most prevalent cause of fatal diseases in developed countries. An antithrombotic agent that can be administered to patients with severe acute thrombotic diseases without the risk of causing hemorrhage, as experienced with antithrombotic/thrombolytic therapy in the treatment of acute ischemic stroke or systemic anticoagulants like ...
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Thrombosis is the most prevalent cause of fatal diseases in developed countries. An antithrombotic agent that can be administered to patients with severe acute thrombotic diseases without the risk of causing hemorrhage, as experienced with antithrombotic/thrombolytic therapy in the treatment of acute ischemic stroke or systemic anticoagulants like ...
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