Results 261 to 270 of about 145,978 (310)
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Blood Coagulation & Fibrinolysis, 2007
For intravenous anticoagulation, heparin has been the mainstay drug, but its use may be contraindicated in heparin-induced thrombocytopenia and thrombosis. Heparin alternatives including direct thrombin inhibitors are available, but clotting assays (e.g.
Taro, Taketomi +4 more
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For intravenous anticoagulation, heparin has been the mainstay drug, but its use may be contraindicated in heparin-induced thrombocytopenia and thrombosis. Heparin alternatives including direct thrombin inhibitors are available, but clotting assays (e.g.
Taro, Taketomi +4 more
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Current Drug Target -Cardiovascular & Hematological Disorders, 2005
L-Mevalonic acid is the distant precursor of cholesterol, in contrast to cholesterol, L-mevalonic acid, its distant precursor gives rise to farnesyl and geranylgeranyl pyrophosphates in relatively few metabolic steps. These isoprenyl pyrophophates covalently conjugate with specific G-proteins and serve as membrane anchors enabling them to carry out ...
J W, Fenton +5 more
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L-Mevalonic acid is the distant precursor of cholesterol, in contrast to cholesterol, L-mevalonic acid, its distant precursor gives rise to farnesyl and geranylgeranyl pyrophosphates in relatively few metabolic steps. These isoprenyl pyrophophates covalently conjugate with specific G-proteins and serve as membrane anchors enabling them to carry out ...
J W, Fenton +5 more
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Physical Chemistry Chemical Physics, 2007
Thrombin is a Na(+)-activated, allosteric serine protease that plays multiple functional roles in blood pathophysiology. Binding of Na(+) is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme. This review summarizes our current understanding of the molecular basis of thrombin allostery with special ...
Enrico, Di Cera +4 more
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Thrombin is a Na(+)-activated, allosteric serine protease that plays multiple functional roles in blood pathophysiology. Binding of Na(+) is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme. This review summarizes our current understanding of the molecular basis of thrombin allostery with special ...
Enrico, Di Cera +4 more
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Attenuation of Thrombin-Induced Brain Edema by Cerebral Thrombin Preconditioning
Stroke, 1999 Background and Purpose —Edema formation after intracerebral hemorrhage has been linked to thrombin toxicity induced by the clot.
Guohua Xi, Richard F Keep, Ya Hua
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Chest, 2003
After generation from prothrombin, thrombin plays multiple roles in the blood coagulation cascade that are mediated by interaction with a number of physiologic substrates, effectors, and inhibitors. Structural and mutagenesis studies have helped unravel the molecular basis of thrombin interactions in the context of both well-established and emerging ...
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After generation from prothrombin, thrombin plays multiple roles in the blood coagulation cascade that are mediated by interaction with a number of physiologic substrates, effectors, and inhibitors. Structural and mutagenesis studies have helped unravel the molecular basis of thrombin interactions in the context of both well-established and emerging ...
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Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation
Thrombosis and Haemostasis, 1997Thrombin mediates acute vascular thrombosis and subsequent vascular lesion formation following mechanical denuding injury or spontaneous atherosclerotic plaque rupture. In the process of generating thrombin Factor VII/VIIa binds avidly with tissue factor (TF) exposed on cellular membranes, and coagulation serine proteases are sequentially cleaved via ...
L A, Harker, S R, Hanson, A B, Kelly
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Seminars in Thrombosis and Hemostasis, 1998
From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombosis, coronary thrombosis, stroke ...
J W, Fenton +3 more
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From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombosis, coronary thrombosis, stroke ...
J W, Fenton +3 more
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Nature, 1946
BARRATT1 found in 1932 that bacteria do not cause the decomposition of thrombin preparations, but rather that this is a chemical process I have shown that the inactivation of thrombin in native blood and in the pure thrombin solution is the same process as that which is caused by an inactivating system in plasma, but which in the preparation is present
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BARRATT1 found in 1932 that bacteria do not cause the decomposition of thrombin preparations, but rather that this is a chemical process I have shown that the inactivation of thrombin in native blood and in the pure thrombin solution is the same process as that which is caused by an inactivating system in plasma, but which in the preparation is present
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Thrombin and Thrombin Inhibitors
1998Thrombin is a 37 kDa glycosylated trypsin-like serine protease that has multiple biological functions. It is formed from a precursor protein, the zymogen prothrombin, by a complex of Factor Xa, Va, phospholipid, and calcium (Tracy et al., 1981). Prothrombin is synthesized by the liver and secreted into the blood stream (Fenton, 1986), where it is ...
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Specific Activities of Bovine Thrombin and Thrombin Components
Thrombosis and Haemostasis, 1972SummaryBovine thrombins (Gel-T) isolated from bioactivated crude prothrombin, obtained from Holstein, Jersey and Hereford single animal plasmas, occur in two distributions: either T1, T2 and T3 as 1:2:1 (Type I), or T1 and T2 as 1:1, with T3 absent or present to the extent of 5% of total Thrombin (Type II).
D F, Waugh, R D, Rosenberg
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