Results 271 to 280 of about 288,586 (288)
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Thrombin inhibitors and thrombin receptor agonists/antagonists
1996Summary The information presented in this article illustrates the feasibility of designing low molecular weight protein mimetics by exploiting the three dimensional array of functional binding elements of the parent protein. In the case of thrombin, the unique mechanism of enzyme inhibition exerted by hirudin is preserved in low molecular weight ...
M.D. Holienberg +5 more
openaire +2 more sources
Expert Opinion on Pharmacotherapy, 2003
This review deals with a newly-developed category of antithrombotic drugs - the direct thrombin inhibitors. These agents interact with thrombin and block its catalytic activity on fibrinogen, platelets and other substrates. Heparin and its derivatives (low molecular weight heparins and the active pentasaccharide) inhibit thrombin and/or other ...
openaire +3 more sources
This review deals with a newly-developed category of antithrombotic drugs - the direct thrombin inhibitors. These agents interact with thrombin and block its catalytic activity on fibrinogen, platelets and other substrates. Heparin and its derivatives (low molecular weight heparins and the active pentasaccharide) inhibit thrombin and/or other ...
openaire +3 more sources
Thrombin—unique coagulation system protein with multifaceted impacts on cancer and metastasis
Cancer Metastasis Review, 2016M. Wojtukiewicz +4 more
semanticscholar +1 more source
Biochimie
Many studies have demonstrated the involvement of proteases in gut physiology and pathophysiology over the recent years. Among them, thrombin has appeared for a long time as an old player only involved in blood clotting upon tissue injury. The fact that thrombin receptors (Protease-Activated Receptors-1 and -4) are expressed and functional in almost ...
openaire +3 more sources
Many studies have demonstrated the involvement of proteases in gut physiology and pathophysiology over the recent years. Among them, thrombin has appeared for a long time as an old player only involved in blood clotting upon tissue injury. The fact that thrombin receptors (Protease-Activated Receptors-1 and -4) are expressed and functional in almost ...
openaire +3 more sources
A dual thrombin receptor system for platelet activation
Nature, 1998M. Kahn +8 more
semanticscholar +1 more source
Protease-activated receptor 3 is a second thrombin receptor in humans
Nature, 1997Hiroaki Ishihara +7 more
semanticscholar +1 more source
The Role of Thrombin and Thrombin Inhibitors in Coronary Angioplasty
Chest, 1995Mir Ali +2 more
openaire +3 more sources