Results 91 to 100 of about 3,126,313 (204)

Successful management of VTE with essential thrombocythemia and cavernous transformation of the portal vein in early pregnancy: a case report

BMC Women's Health
Due to the thrombohemorrhagic potential of essential thrombocythemia, pregnancy complicated by essential thrombocythemia should be recognized as a risk factor for obstetric complications.
Xin Kang, Shibin Hong, Chengxi Tan, Wen Di, Ning Zhang   +4 more
doaj   +1 more source

The role of oxidative stress in essential thrombocythemia [PDF]

Archives of the Balkan Medical Union, 2018
In patients with myeloproliferative neoplasms (MPNs), including essential thrombocythemia, current studies have demonstrated a JAK2V617F-dependent reactive oxygen species (ROS) elevation partially mediated by a decrease in catalase expression associated ...
Cornel Moisă, Mihnea-Alexandru Găman, Emilia Georgiana Pascu, Oana Cătălina Drăgușin, Alexandru Dan Assani, Mirela-Elena Epîngeac, Amelia-Maria Găman   +6 more
doaj  

Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group

Haematologica, 2017
The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life.
Holly L. Geyer, Heidi Kosiorek, Amylou C. Dueck, Robyn Scherber, Stefanie Slot, Sonja Zweegman, Peter AW te Boekhorst, Zhenya Senyak, Harry C. Schouten, Federico Sackmann, Ana Kerguelen Fuentes, Dolores Hernández-Maraver, Heike L. Pahl, Martin Griesshammer, Frank Stegelmann, Konstanze Döhner, Thomas Lehmann, Karin Bonatz, Andreas Reiter, Francoise Boyer, Gabriel Etienne, Jean-Christophe Ianotto, Dana Ranta, Lydia Roy, Jean-Yves Cahn, Claire N. Harrison, Deepti Radia, Pablo Muxi, Norman Maldonado, Carlos Besses, Francisco Cervantes, Peter L. Johansson, Tiziano Barbui, Giovanni Barosi, Alessandro M. Vannucchi, Chiara Paoli, Francesco Passamonti, Bjorn Andreasson, Maria L Ferrari, Alessandro Rambaldi, Jan Samuelsson, Keith Cannon, Gunnar Birgegard, Zhijian Xiao, Zefeng Xu, Yue Zhang, Xiujuan Sun, Junqing Xu, Jean-Jacques Kiladjian, Peihong Zhang, Robert Peter Gale, Ruben A. Mesa   +51 more
doaj   +1 more source

The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors

Advances in Hematology, 2020
Essential thrombocythemia is a rare hematological malignancy with good overall survival, but moderate to high risk of developing arterial or venous thrombosis lifelong.
S. Mancuso, V. Accurso, M. Santoro, S. Raso, A. Contrino, A. Perez, F. Di Piazza, A. Florena, A. Russo, S. Siragusa   +9 more
semanticscholar   +1 more source

The Immunological Consequences of Clonal Hematopoiesis in Heart Failure

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Inflammation is increasingly recognized as a central driver of heart failure (HF), particularly in older adults, yet the underlying immune mechanisms remain diverse and incompletely understood. Clonal hematopoiesis (CH), defined by the expansion of somatically mutated hematopoietic clones, has emerged as a risk factor for the development of ...
Megan A. Evans, Kenneth Walsh
wiley   +1 more source

Diagnosis and Management of Essential Thrombocythemia: A Comprehensive Review [PDF]

Documenta Haematologica
Myeloproliferative neoplasms, including essential thrombocythemia, are characterized by clonal proliferations of hematopoietic stem cells, leading to an increase in mature myeloid lineage cells.
Sandra LAZAR, Despina Calamar POPOVICI, Oana SARAU, Hortensia IONITA, Claudiu Octavian IONITA, Dacian Nicolae OROS, Ioana IONITA   +6 more
doaj   +1 more source

The JAK2V617F and CALR mutations and risk of cancer, cardiovascular diseases, and all‐cause mortality

Journal of Internal Medicine, Volume 299, Issue 1, Page 79-94, January 2026.
Abstract Background Clonal hematopoiesis (CH) is associated with adverse outcomes. We hypothesized that CH (JAK2V617F and CALR) is associated with cancer, vascular disease, and all‐cause mortality, even at a variant allele frequency (VAF) <1%. Methods We screened 19,832 individuals from the Danish General Suburban Population Study for JAK2V617F and ...
Morten Kranker Larsen, Vibe Skov, Lasse Kjær, Christina Schjellerup Eickhardt‐Dalbøge, Trine Alma Knudsen, Marie Hvelplund Kristiansen, Anders Lindholm Sørensen, Sabrina Cordua, Troels Wienecke, Mette Grymer Jensen, Morten Andersen, Johnny T. Ottesen, Johanne Gudmand‐Høyer, Jordan Andrew Snyder, Henrik Enghusen Poulsen, Thomas Stiehl, Christina Ellervik, Hans Carl Hasselbalch   +17 more
wiley   +1 more source

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. [PDF]

, 2014
Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation.
de Haan, Gerald, Green, Anthony R, Kent, David G, Prick, Janine   +3 more
core   +1 more source

Acute megakaryoblastic transformation from essential thrombocythemia

Human Pathology: Case Reports, 2017
Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative neoplasm characterized by sustained thrombocytosis. Its transformation into acute leukemia is a rare event (5% at 20 years).
Tariq M. Roshan, Ashish B. Rajput, Philip Berardi, Ruth Padmore   +3 more
doaj   +1 more source

Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia

Haematologica, 2009
Background Most cell types, including blood - and vascular cells, produce microparticles upon activation. Since cellular microparticles are known to be elevated in thromboembolic diseases, we hypothesized a role for microparticles in the pathogenesis of ...
Marijke C. Trappenburg, Muriel van Schilfgaarde, Marina Marchetti, Henri M. Spronk, Hugo ten Cate, Anja Leyte, Wim E. Terpstra, Anna Falanga   +7 more
doaj   +1 more source