Results 81 to 90 of about 15,175 (215)

Single‐Agent Selinexor Versus Physician's Choice in Previously Treated Myelofibrosis: Results From the Phase 2 XPORT‐035 Study

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Background Janus kinase inhibitors (JAKis), the current standard of care for myelofibrosis (MF), provide clinical benefit, but responses are frequently incomplete, non‐durable, and associated with cytopenias, underscoring the need for therapies with novel mechanisms of action.
Sebastian Grosicki, Habte Yimer, Rosa Ayala, Suning Chen, Hong Liu, Françoise Boyer, Paola Guglielmelli, Marco Brociner, Paolo Sportoletti, Gabor Mikala, Panagiotis Tsirigotis, Jin Zhang, Tomer Mark, Yi Chai, Andrea Ellero, Alessandro Lucchesi   +15 more
wiley   +1 more source

Atypical Myocardial Infarction with Apical Thrombus and Systemic Embolism: A Rare Presentation of Likely JAK2 V617F-Positive Myeloproliferative Neoplasm

Case Reports in Oncological Medicine, 2020
A few types of myeloproliferative neoplasms may be significant for Janus-associated kinase 2 mutation, JAK2 V617F, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
Muhammed Atere, Rana Al-Zakhari, Jennifer Collins, Francesco Rotatori, Lloyd Muzangwa   +4 more
doaj   +1 more source

[Essential thrombocythemia in pregnancy].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 1993
A 30-year-old woman was admitted to our hospital because of thrombocythemia during pregnancy. Her leukocyte count was 10,000/microliters, Hb was 11.7 g/dl, and platelet count 181.9 x 10(4)/microliter. Bone marrow aspirate showed an increase in megakaryocytes (255/microliters). Both Ph1 chromosome and bcr rearrangement were negative.
TOMIYAMA, Junji, KOMENO, Takuya, NANKI, Toshihiro, KANEKO, Hiroshi, KUDO, Hideki, TERATANI, Toshio, MORIYA, Kazuto   +6 more
openaire   +2 more sources

Essential Thrombocythemia in Young Women

, 2023
Background: Essential thrombocythemia (ET) is a rare disease in which there is an increase in the platelet count of more than 450,000/mm3. An increase in the number of platelets occurs due to increased proliferation of megakaryocyte series.
Anggit Pungkas Wibowo, Eifel Faheri, Wibowo, Anggit Pungkas   +2 more
core   +1 more source

Multiple venous and arterial thromboses of the gallbladder causing acute cholecystitis. A previously undescribed complication of essential thrombocythemia(†)(†)Supported in part by Fundación Clínica Médica Sur.

Annals of Hepatology, 2011
Well established complications of essential thrombocythemia are multiple thrombohemorrhagic phenomena in various abdominal organs. We describe the case of a 22 year old man with essential thrombocythemia and thrombosis of the mesenteric and splenic veins
Gabriela Picón-Coronel, Fredy Chablé-Montero, Arturo Ángeles-Ángeles, Jorge Albores-Saavedra, Dr.   +3 more
doaj   +1 more source

Clinical benefit and predictors of response to momelotinib after ruxolitinib failure: A cooperative real‐world study

Cancer, Volume 132, Issue 10, 15 May 2026.
Momelotinib demonstrated robust real‐world activity after ruxolitinib failure, with clinically meaningful improvements in spleen (≥50% spleen length reduction, 30.0%), symptoms (≥50% total symptoms score reduction, 39.2%), and anemia (major response, 35.7%) at 6 months.
Francesca Palandri, Monia Marchetti, Elena M. Elli, Alessandro Isidori, Ilaria Gianesello, Chiara Sartor, Novella Pugliese, Maria Di Perna, Erika Morsia, Susanna Gallo, Federico Itri, Vittorio Montefusco, Elena Crisà, Annalisa Biagi, Eloise Beggiato, Olga Mulas, Giulia Benevolo, Elisabetta Abruzzese, Marco Santoro, Alessandra Iurlo, Elisabetta Calistri, Marco Rossi, Bruno Martino, Mario Tiribelli, Carmen Fava, Arbana Dizdari, Monica Crugnola, Andrea Duminuco, Amedeo Votto, Selene Guerzoni, Giovanni Caocci, Fabrizio Pane, Francesco Lanza, Filippo Branzanti, Alessandra Dedola, Flavia Salvatore, Florian H. Heidel, Massimo Breccia, Giuseppe A. Palumbo, Andrew T. Kuykendall, Alessandro Lucchesi, Sara Galimberti   +41 more
wiley   +1 more source

Ischemic Stroke as First Manifestation of Essential Thrombocythemia

, 1995
Background Ischemic stroke as a presenting sign of essential thrombocythemia has been infrequently reported. We describe six patients in whom cerebrovascular disease was the first manifestation of this myeloproliferative disease.
Jordi Sans-Sabrafen, Pilar Acín, Adrià Arboix, Carles Besses, Montserrat Oliveres, Lourdes Florensa, Juan B. Massons   +6 more
core   +1 more source

Essential thrombocythemia with BCR/ABL rearrangement

, 1996
Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl ...
Liang, RHS, Vivian Chan, Kwong, YL, Chan, TK, Chan, V, R.H.S. Liang, E.K.W. Chiu, Chiu, EKW, T.K. Chan, Y.L. Kwong   +9 more
core   +1 more source

Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia

Haematologica, 2009
Background Most cell types, including blood - and vascular cells, produce microparticles upon activation. Since cellular microparticles are known to be elevated in thromboembolic diseases, we hypothesized a role for microparticles in the pathogenesis of ...
Marijke C. Trappenburg, Muriel van Schilfgaarde, Marina Marchetti, Henri M. Spronk, Hugo ten Cate, Anja Leyte, Wim E. Terpstra, Anna Falanga   +7 more
doaj   +1 more source

Essential Thrombocythemia Complicated by Addison's Disease: A Case of Overlapping Endocrine and Hematological Disorders

Hematology, Transfusion and Cell Therapy
This case report delves into the intricacies of managing a patient diagnosed with both essential thrombocythemia and Addison's disease, illustrating the challenges and importance of an integrated approach to complex, coexisting conditions.
Meryem SENER, Kaan NISANOGLU, Candas MUMCU, Bengisu Ece DUMAN, Berra Nur ISCI, Emre BAL, Irem KABALCI KADIOGLU, Birol GUVENC   +7 more
doaj   +1 more source