Results 31 to 40 of about 182,230 (304)

Older patients with COVID‐19 and neuropsychiatric conditions: A study of risk factors for mortality

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Background Little is known about risk factors for mortality in older patients with COVID‐19 and neuropsychiatric conditions. Methods We conducted a multicentric retrospective observational study at Assistance Publique‐Hôpitaux de Paris. We selected inpatients aged 70 years or older, with COVID‐19 and preexisting neuropsychiatric comorbidities
Vi‐Huong Nguyen‐Michel, Marion Houot, Cécile Delorme, Aude Sangaré, Ana Gales, Valerio Frazzini, Aurélie Hanin, Djamal Aissani, Thanh Trân, Bruno Oquendo, Flora Ketz, Carmelo Lafuente‐Lafuente, Christel Oasi, Kiyoka Kinugawa, Gaëlle Ouvrard, Renata Ursu, Bertrand Degos, Benjamin Rohaut, Sophie Demeret, Virginie Lambrecq, Vincent Navarro, Emmanuel Fournier, Jean‐Christophe Corvol, Alaina Borden   +23 more
wiley   +1 more source

Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus.

PLoS ONE, 2019
ObjectivesTo investigate the prevalence, clinical characteristics, and prognosis of thrombocytopenia (TP) in Chinese patients with systemic lupus erythematosus (SLE).MethodsThe study was conducted based on the Chinese SLE Treatment and Research group ...
N Jiang, M Li, M Zhang, J Xu, L Jiang, L Gong, F Wu, J Gu, J Zhao, Y Xiang, Z Wang, Y Zhao, X Zeng, CSTAR co-authors   +13 more
doaj   +1 more source

Immune Thrombocytopenia [PDF]

New England Journal of Medicine, 2019
This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors’ clinical recommendations.
Cooper, Nichola, Ghanima, Waleed Khalid
openaire   +2 more sources

Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity

Folia Medica Indonesiana, 2023
Highlights: • This is the first systematic review investigating thrombocytopenia and its association with retinopathy of prematurity. • Thrombocytopenia can be a useful clinical biomarker in retinopathy of prematurity screening, considering the quick,
I Wayan Eka Sutyawan, Ni Made Ayu Surasmiati, Putu Anindya Agrasidi, Priscilla Dwianggita, Stephanus Anggara Anggara   +4 more
doaj   +1 more source

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]

, 2020
Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4-heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT).
arxiv   +1 more source

Phase 2 results of lisocabtagene maraleucel in Japanese patients with relapsed/refractory aggressive B‐cell non‐Hodgkin lymphoma

Cancer Medicine, Volume 11, Issue 24, Page 4889-4899, December 2022., 2022
This analysis assessed safety and efficacy of lisocabtagene maraleucel (liso‐cel), an autologous CD‐19‐directed CAR T‐cell product, in Japanese patients with R/R aggressive LBCL in Cohort 3 of TRANSCEND WORLD (NCT03484702). Liso‐cel demonstrated meaningful efficacy and a manageable safety profile in Japanese patients with R/R LBCL.
Shinichi Makita, Go Yamamoto, Dai Maruyama, Yuki Asano‐Mori, Daisuke Kaji, Revathi Ananthakrishnan, Ken Ogasawara, Lara Stepan, Claudia Schusterbauer, Nils Rettby, Jens Hasskarl, Koji Izutsu   +11 more
wiley   +1 more source

Thrombocytopenia and increased risk of adverse outcome in COVID-19 patients [PDF]

PeerJ, 2022
Background Thrombocytopenia was common in the coronavirus disease 2019 (COVID-19) patients during the infection, while the role of thrombocytopenia in COVID-19 pathogenesis and its relationship with systemic host response remained obscure.
Yang Yuan, Gang Wang, Xi Chen, Xiao-Lei Ye, Xiao-Kun Li, Rui Li, Wan-Li Jiang, Hao-Long Zeng, Juan Du, Xiao-Ai Zhang, Hao Li, Li-Qun Fang, Qing-Bin Lu, Wei Liu   +13 more
doaj   +2 more sources

Treatment‐related adverse events of antibody–drug conjugates in clinical trials: A systematic review and meta‐analysis

Cancer, Volume 129, Issue 2, Page 283-295, 15 January 2023., 2023
Abstract Background Antibody–drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance. Methods In a systematic review and meta‐analysis of data gathered from different scientific databases ...
Youwen Zhu, Kun Liu, Kailing Wang, Hong Zhu   +3 more
wiley   +1 more source

Management of thrombocytopenia [PDF]

F1000Prime Reports, 2014
Thrombocytopenia is one of the most common hematologic disorders, characterized by an abnormally low number of platelets from multiple causes. The normal count of thrombocytes (platelets) is between 150,000 and 450,000 per microliter. The clinical expression of thrombocytopenia has broad variation from asymptomatic to life-threatening bleeding. Various
James B. Bussel, Marina Izak
openaire   +3 more sources

Radiosensitization of calreticulin‐overexpressing human glioma cell line by the polyphenolic acetate 7, 8‐diacetoxy‐4‐methylcoumarin

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Calreticulin (CRT), an endoplasmic reticulum–resident protein generally overexpressed in cancer cells, is associated with radiation resistance. CRT shows higher transacetylase activity, as shown by us earlier, in the presence of the polyphenolic acetates (like 7, 8‐diacetoxy‐4‐methylcoumarin, DAMC) and modifies the activity of a ...
Amit Verma, Aastha Arora, Anant N Bhatt, Mohan B Arya, Ashok K Prasad, Virinder S Parmar, Bilikere S Dwarakanath   +6 more
wiley   +1 more source