Results 41 to 50 of about 3,493 (156)

MRP8‐Cre Transgenic Mice Are Resistant to Weight Gain and Diet‐Induced Obesity Independently of Neutrophils

European Journal of Immunology, Volume 56, Issue 9, September 2026.
The MRP8Cre mouse model is frequently used to investigate the biology of neutrophils. This study reports that MRP8Cre transgenic have a lower body weight and improved metabolic health, especially after high fat diet feeding, which correlates with decreased Serpine1/PAI‐1 expression in metabolic organs. Image created with BioRender.com. ABSTRACT Obesity
Stephan Forisch, Fatemeh Soltani, Laia Salvat Costa, Beatriz M. Cardoso, Yaiza Moreno Galiano, Cedric Duval, Robert A. S. Ariëns, Navdeep S. Chandel, Mari T. Kaartinen, Stefanie K. Wculek   +9 more
wiley   +1 more source

Thromboinflammation vs. immunothrombosis: strategies for overcoming anticoagulant resistance in COVID-19 and other hyperinflammatory diseases. Is ROTEM helpful or not?

Frontiers in Immunology
Thrombosis and inflammation are closely interconnected. Systemic inflammation activates the coagulation system, while components of the coagulation system can, in turn, significantly influence the inflammatory response.
Lou M. Almskog, Lou M. Almskog, Anna Ågren, Anna Ågren, Anna Ågren   +4 more
doaj   +1 more source

Case Report: Concomitant Massive Cerebral Venous Thrombosis and Internal Iliac Vein Thrombosis Related to Paucisymptomatic COVID-19 Infection

Frontiers in Neurology, 2021
Thrombotic complications are common in COVID-19 patients, but cerebral venous system involvement, timing after infection, optimal treatment, and long-term outcome are uncertain.
Simone Beretta, Simone Beretta, Simone Beretta, Fulvio Da Re, Fulvio Da Re, Fulvio Da Re, Valentina Francioni, Paolo Remida, Benedetta Storti, Lorenzo Fumagalli, Maria Luisa Piatti, Patrizia Santoro, Diletta Cereda, Claudia Cutellè, Fiammetta Pirro, Danilo Antonio Montisano, Francesca Beretta, Francesco Pasini, Annalisa Cavallero, Ildebrando Appollonio, Ildebrando Appollonio, Ildebrando Appollonio, Carlo Ferrarese, Carlo Ferrarese, Carlo Ferrarese   +24 more
doaj   +1 more source

Toward Individualized Atherosclerosis Therapy: Clinical Endotypes, Programmable Therapeutics, and Delivery Constraints

Medicine Bulletin, Volume 2, Issue 4, Page 388-405, September 2026.
ABSTRACT Atherosclerosis remains the dominant substrate of atherosclerotic cardiovascular disease (ASCVD), yet recurrent events persist even when LDL cholesterol is driven to guideline targets, underscoring residual risk as a central limitation of contemporary prevention.
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tataiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

Role of defensins in immunothrombosis

Rheumatology &Autoimmunity, Volume 6, Issue 3, Page 138-148, September 2026.
Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
wiley   +1 more source

Increased NETosis in Patients With Heart Failure Is Associated With Macrophage Activation Towards a Proinflammatory Phenotype

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT In this study, we tested the hypothesis that there is an interaction between neutrophils (N) undergoing NETosis and the activation of macrophages (Mf) in the myocardium of patients with heart failure (HF). Ventricular biopsies were examined from patients with HF due to dilated (DCM, n = 7), ischemic (ICM, n = 7), or inflammatory (InfCM, n = 7)
Sawa Kostin, Hector A. Cabrera‐Fuentes, Manfred Richter, Florian Krizanic, Oliver Ritter, William A. Boisvert, Klaus T. Preissner, Theodoros Kelesidis, Gerasimos Siasos, Nikolaos Pagonas   +9 more
wiley   +1 more source

Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase‐A1

Physiological Reports, Volume 14, Issue 17, September 2026.
Abstract Vascular expansive remodeling is involved in atherosclerosis/restenosis; however, its mechanisms need further investigation. Protein‐disulfide isomerase (PDIA1), a redox chaperone from the endoplasmic reticulum and cell surface, supports vascular smooth muscle mechanoadaptation.
Júlia Martins Felipe de Souza, Tiphany Coralie De Bessa, Amanda de Almeida Silva, Carolina Gonçalves Fernandes, Leonardo Yuji Tanaka, Francisco Rafael Martins Laurindo   +5 more
wiley   +1 more source

The Immuno‐Cardiovascular Storm of Pre‐Eclampsia: Cytokine‐Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Placental ischemia in pre‐eclampsia initiates cytokine‐driven endothelial dysfunction, angiogenic imbalance, oxidative stress, and thromboinflammation. Elevated TNF‐α, IL‐6, IL‐17, sFlt‐1, and complement activation promote vasoconstriction, thrombosis, and cardiovascular instability.
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Thromboinflammatory biomarkers in obstetric pathophysiology: Predictive insights into placental insufficiency and feto‐maternal adverse outcomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Etude de la thromboinflammation à la phase aiguë de l'AVC ischémique : physiopathologie et nouvelles stratégies thérapeutiques

Ischemic stroke occurs when a cerebral artery is occluded by a thrombus and is a leading cause of death and disability worldwide. Risk factors such as diabetes and hypertension increase stroke incidence and severity. Recanalization is the only treatment:
Perrot, Astride
core   +1 more source