Results 31 to 40 of about 3,493 (156)

Mechanisms, diagnostics and therapies for thromboinflammation

, 2022
Thrombosis, the disruption of blood flow in the circulation by a blood clot (thrombus), can cause serious and life-threatening disease and still forms an important healthcare challenge. Thrombosis resulting from cardiovascular disease, such as myocardial
Clark, Chantal Cheryl
core  

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke

Frontiers in Immunology, 2019
von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ibα (GPIbα).
Frederik Denorme, Karen Vanhoorelbeke, Simon F. De Meyer   +2 more
doaj   +1 more source

Hemostatic laboratory derangements in COVID-19 with a focus on platelet count

Platelets, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease in 2019 (COVID-19) which rapidly evolved from an outbreak in Wuhan, China into a pandemic that has resulted in over millions of infections and over ...
Ariunzaya Amgalan, Maha Othman
doaj   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Cardiometabolic Protein Profile Changes During Gender‐Affirming Hormone Therapy: A Prospective Clinical Study

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Cardiovascular disease (CVD) risk is elevated in transgender individuals during gender‐affirming hormone therapy (GAHT) with expected different mechanisms between T‐ and E2‐based GAHT. We investigated prospective changes in cardiometabolic proteins relating to complement, inflammation, and transport during GAHT.
Emilie Bukh Madsen, Louise Lehmann Christensen, Sara Ravn Bach, Louise Skøttrup Christiansen, Mathilde Kamp Nørlund, Tine Taulbjerg Kristensen, Guy T'Sjoen, Anne Pernille Hermann, Camilla Viola Buskbjerg Palm, Jan Frystyk, Marianne Skovsager Andersen, Martin Overgaard, Dorte Glintborg   +12 more
wiley   +1 more source

The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients

Акушерство, гинекология и репродукция
The results of recent studies show that tumor biology, coagulation activation, and inflammatory reactions profoundly contribute to the thrombosis pathogenesis in cancer as well as tumor progression, metastasis, and developing chemoresistance.
A. D. Makatsariya, E. V. Slukhanchuk, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, L. A. Ashrafyan, V. N. Serov, A. Е. Voynovskiy, J. Yu. Ungiadze, A. V. Lazarchuk, M. V. Tretyakova, N. A. Makatsariya, P. V. Salnikova, N. R. Gashimova, K. N. Grigoreva, K. L. Zakashansky, I. Elalamy, J.-C. Gris   +17 more
doaj   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, Volume 100, Issue 4, Page 824-840, October 2026.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in
Jeremy B. Ducharme, Martin M. Schonk, Miguel A. Gutierrez‐Monreal, Leonardo F. Ferreira, Karyn A. Esser, Andrew R. Judge, Sarah M. Judge   +6 more
wiley   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

Neutrophil extracellular traps as markers of thromboinflammation in the pathogenesis of female genital tract and breast malignant neoplasms

Акушерство, гинекология и репродукция, 2022
Introduction. Thrombosis is a formidable complication of the oncological process that still profoundly contributes to overall mortality despite the anticoagulant use.
E. V. Slukhanchuk, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, J.-Ch. Gris, I. Elalamy, A. D. Makatsariya   +6 more
doaj   +1 more source