Results 161 to 170 of about 17,882 (212)
Some of the next articles are maybe not open access.
Journal of Thrombosis and Haemostasis, 2003
Since its discovery as a critical cofactor in the initiation of the protein C (PC) anticoagulant pathway [1,2], biochemical and structural investigations, combined with in vivo analyses of genetically engineered mice have revealed new, and in part PC- and thrombin-independent aspects of thrombomodulin (TM) function in fibrinolysis and inflammation, and
H, Weiler, B H, Isermann
openaire +2 more sources
Since its discovery as a critical cofactor in the initiation of the protein C (PC) anticoagulant pathway [1,2], biochemical and structural investigations, combined with in vivo analyses of genetically engineered mice have revealed new, and in part PC- and thrombin-independent aspects of thrombomodulin (TM) function in fibrinolysis and inflammation, and
H, Weiler, B H, Isermann
openaire +2 more sources
Thrombomodulin Structure and Function
Thrombosis and Haemostasis, 1997Thrombomodulin is protein cofactor expressed on endothelial cell surfaces that modifies the substrate specificity of thrombin, apparently by an allosteric mechanism. The thrombin-thrombomodulin complex activates protein C, initiating an essential anticoagulant pathway.
J Evan Sadler
exaly +3 more sources
Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma [PDF]
Journal of Thrombosis and Haemostasis, 2005 Endothelial cell membrane-bound thrombomodulin (TM) plays a critical role as a cofactor in the protein C pathway, important in regulating coagulation as well as inflammation. Heterogeneous soluble TM fragments circulate in the plasma and are found at increased levels in various diseases such as cardiovascular disease and diabetes, and in ischemic and ...
A-K, Ohlin, K, Larsson, M, Hansson
exaly +3 more sources
The Role of Thrombomodulin in Malignancy
Seminars in Thrombosis and Hemostasis, 2007More than 150 years ago, Trousseau first suggested a link between cancer and thrombosis. Although this link has been widely described subsequently, the underlying mechanism still remains unclear. Thrombomodulin (TM), a natural endothelial anticoagulant, has proved itself to be an exciting molecule of many functions, not least of those in inflammation ...
Ann M, Hanly, Desmond C, Winter
openaire +2 more sources
Thrombomodulin activity and localization
The International Journal of Developmental Biology, 1993An overview on the properties, actions and localization of thrombomodulin (TM) in situations of tissue injury and in selected tumors is presented. The localization and activity of TM after injury to vascular endothelium shows that following balloon catheter denudation of the endothelium of the rabbit aorta, the activity and immunohistochemical staining
L M, Fink +9 more
openaire +2 more sources
Neuroprotection by Recombinant Thrombomodulin
Thrombosis and Haemostasis, 2000SummaryWe examined whether recombinant human soluble thrombomodulin (rhs-TM) reduces compression trauma-induced spinal cord injury through protein C activation in rats. Administration of rhs-TM, either before or after the induction of spinal cord injury (SCI), markedly reduced the resulting motor disturbances. However, neither rhs-TM pretreated with an
Y, Taoka +3 more
openaire +2 more sources
Pharmacokinetics of recombinant human soluble thrombomodulin, thrombomodulin alfa in the rat
Xenobiotica, 20091. The study aimed to investigate the pharmacokinetics of thrombomodulin alpha (TM-alpha), human-soluble thrombomodulin in rats. 2. Intravenously administered TM-alpha was eliminated in two phases (T(1/2 alpha) = 0.2-0.3 h and T(1/2 beta) = 6-8 h), and the elimination curve was linear in a dose range of 10-250 microg kg(-1).
K, Tsuruta +6 more
exaly +3 more sources
Minerva anestesiologica, 2013
Thrombomodulin has a pivotal role in the protein C system that is important in the pathogenesis of sepsis. In sepsis, endothelial cell expression of thrombomodulin is strongly downregulated, causing an impaired activation of protein C that is central in the modulation of coagulation activation and inflammatory processes.
Levi, M. [=Marcel M.], van der Poll, T.
openaire +2 more sources
Thrombomodulin has a pivotal role in the protein C system that is important in the pathogenesis of sepsis. In sepsis, endothelial cell expression of thrombomodulin is strongly downregulated, causing an impaired activation of protein C that is central in the modulation of coagulation activation and inflammatory processes.
Levi, M. [=Marcel M.], van der Poll, T.
openaire +2 more sources
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001
Thrombomodulin (TM), a membrane-bound receptor for thrombin on the endothelial cell surface, contributes to the regulation of the coagulation system. TM is known to exist in human plasma and urine as soluble forms. We purified soluble TM from human urine (MR-33) and investigated the anticoagulant effects of MR-33 in vitro and in vivo.
Y, Ohmori, Y, Takahashi
openaire +1 more source
Thrombomodulin (TM), a membrane-bound receptor for thrombin on the endothelial cell surface, contributes to the regulation of the coagulation system. TM is known to exist in human plasma and urine as soluble forms. We purified soluble TM from human urine (MR-33) and investigated the anticoagulant effects of MR-33 in vitro and in vivo.
Y, Ohmori, Y, Takahashi
openaire +1 more source
Neurology, 2012
In this issue of Neurology ®, Giwa et al.1 report robust expression of thrombomodulin (TM) in small vessel disease, i.e., in small brain arteries or arterioles that exhibit the typical hyalinized thickening characteristic of chronic hypertensive changes.
openaire +2 more sources
In this issue of Neurology ®, Giwa et al.1 report robust expression of thrombomodulin (TM) in small vessel disease, i.e., in small brain arteries or arterioles that exhibit the typical hyalinized thickening characteristic of chronic hypertensive changes.
openaire +2 more sources