Results 171 to 180 of about 28,500 (228)
Inflammatory, fibrotic and endothelial biomarker profiles in COVID-19 patients during and following hospitalization. [PDF]
Sci RepDarawshy F +4 more
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Efficacy and Safety of Recombinant Human Soluble Thrombomodulin in Patients With Sepsis-Induced Disseminated Intravascular Coagulation After Emergency Surgery. [PDF]
CureusNagata K, Fujikawa T, Matsuoka T.
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Journal of Thrombosis and Haemostasis, 2003
Since its discovery as a critical cofactor in the initiation of the protein C (PC) anticoagulant pathway [1,2], biochemical and structural investigations, combined with in vivo analyses of genetically engineered mice have revealed new, and in part PC- and thrombin-independent aspects of thrombomodulin (TM) function in fibrinolysis and inflammation, and
H, Weiler, B H, Isermann
openaire +2 more sources
Since its discovery as a critical cofactor in the initiation of the protein C (PC) anticoagulant pathway [1,2], biochemical and structural investigations, combined with in vivo analyses of genetically engineered mice have revealed new, and in part PC- and thrombin-independent aspects of thrombomodulin (TM) function in fibrinolysis and inflammation, and
H, Weiler, B H, Isermann
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Atherosclerosis, 1994
Recently Blann [l] reported an increase in serum levels of von Willebrand factor antigen in smokers immediately after they had smoked two cigarettes. The von Willebrand factor is a specific endothelial constituent and its increased release indicates endothelial injury.
P. Kubisz, I. Markuljak, S. Cronberg
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Recently Blann [l] reported an increase in serum levels of von Willebrand factor antigen in smokers immediately after they had smoked two cigarettes. The von Willebrand factor is a specific endothelial constituent and its increased release indicates endothelial injury.
P. Kubisz, I. Markuljak, S. Cronberg
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Neuroprotection by Recombinant Thrombomodulin
Thrombosis and Haemostasis, 2000SummaryWe examined whether recombinant human soluble thrombomodulin (rhs-TM) reduces compression trauma-induced spinal cord injury through protein C activation in rats. Administration of rhs-TM, either before or after the induction of spinal cord injury (SCI), markedly reduced the resulting motor disturbances. However, neither rhs-TM pretreated with an
Y, Taoka +3 more
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Pharmacokinetics of recombinant human soluble thrombomodulin, thrombomodulin alfa in the rat
Xenobiotica, 20091. The study aimed to investigate the pharmacokinetics of thrombomodulin alpha (TM-alpha), human-soluble thrombomodulin in rats. 2. Intravenously administered TM-alpha was eliminated in two phases (T(1/2 alpha) = 0.2-0.3 h and T(1/2 beta) = 6-8 h), and the elimination curve was linear in a dose range of 10-250 microg kg(-1).
K, Tsuruta +6 more
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001
Thrombomodulin (TM), a membrane-bound receptor for thrombin on the endothelial cell surface, contributes to the regulation of the coagulation system. TM is known to exist in human plasma and urine as soluble forms. We purified soluble TM from human urine (MR-33) and investigated the anticoagulant effects of MR-33 in vitro and in vivo.
Y, Ohmori, Y, Takahashi
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Thrombomodulin (TM), a membrane-bound receptor for thrombin on the endothelial cell surface, contributes to the regulation of the coagulation system. TM is known to exist in human plasma and urine as soluble forms. We purified soluble TM from human urine (MR-33) and investigated the anticoagulant effects of MR-33 in vitro and in vivo.
Y, Ohmori, Y, Takahashi
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Thrombosis Research, 2013
We assessed the safety and effectiveness of recombinant soluble thrombomodulin (thrombomodulin alfa, TM-α) in the treatment of disseminated intravascular coagulation (DIC) in a post-marketing surveillance.The cases of 3548 patients with DIC caused by infection (n=2516, Infection-DIC) or hematological malignancy (n=1032, Hemat-DIC) were analyzed and ...
Jun, Mimuro +7 more
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We assessed the safety and effectiveness of recombinant soluble thrombomodulin (thrombomodulin alfa, TM-α) in the treatment of disseminated intravascular coagulation (DIC) in a post-marketing surveillance.The cases of 3548 patients with DIC caused by infection (n=2516, Infection-DIC) or hematological malignancy (n=1032, Hemat-DIC) were analyzed and ...
Jun, Mimuro +7 more
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Minerva anestesiologica, 2013
Thrombomodulin has a pivotal role in the protein C system that is important in the pathogenesis of sepsis. In sepsis, endothelial cell expression of thrombomodulin is strongly downregulated, causing an impaired activation of protein C that is central in the modulation of coagulation activation and inflammatory processes.
Levi, M. [=Marcel M.], van der Poll, T.
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Thrombomodulin has a pivotal role in the protein C system that is important in the pathogenesis of sepsis. In sepsis, endothelial cell expression of thrombomodulin is strongly downregulated, causing an impaired activation of protein C that is central in the modulation of coagulation activation and inflammatory processes.
Levi, M. [=Marcel M.], van der Poll, T.
openaire +2 more sources