Results 11 to 20 of about 60,582 (221)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Aromatic Amines Exert Contrasting Effects on the Anticoagulant Effect of Acetaldehyde upon APTT

Advances in Hematology, 2014
The pharmacological effects of amphetamine, procaine, procainamide, DOPA, isoproterenol, and atenolol upon activated partial thromboplastin time in the absence and presence of acetaldehyde have been investigated.
La'Teese Hall, Sarah J. Murrey, Arthur S. Brecher   +2 more
doaj   +1 more source

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes [PDF]

International Journal of Basic Science in Medicine, 2016
Background: Circadian rhythm and physical activity are factors that influence the homeostasis of blood. This study aimed to investigate the effect of exhaustive exercise in the morning and evening on the blood hemostasis in female athletes.
Salimeh Mahmoodinezhad, Saeid Shakerian, Akbar Ghalavand, Pezhman Motamedi, Mojtaba Delaramnasab   +4 more
doaj   +1 more source

Association of coagulation profile with microvascular complications and glycemic control in type 2 diabetes mellitus – a study at a tertiary care center in Delhi

Hematology, Transfusion and Cell Therapy, 2019
Introduction: Type 2 diabetes mellitus, characterized by insulin resistance, corresponds to approximately 90% of cases of diabetes worldwide. Hyperglycemia in diabetes contributes to hyperfibrinogenemia and activates the coagulation cascade thereby ...
Charu Agarwal, Kashish Bansal, Mukta Pujani, Kanika Singh, Varsha Chauhan, Deepshikha Rana, Shveta Lukhmana   +6 more
doaj   +1 more source

Assessment of Hemostasis after Plasma Exchange Using Rotational Thrombelastometry (ROTEM). [PDF]

PLoS ONE, 2015
Therapeutic plasma exchange (TPE)-based protocols immediately before cadaveric donor kidney transplantation have been extensively used in highly sensitized recipients.
Gerold Thölking, Rolf Mesters, Ralf Dittrich, Hermann Pavenstädt, Philipp Kümpers, Stefan Reuter   +5 more
doaj   +1 more source

Disseminated intravascular coagulation in dogs with gastric dilatation-volvulus syndrome

Veterinární Medicína, 2013
Gastric dilatation and volvulus syndrome is associated with changes in haemostatic profiles. The aims of this study were to compare selected haemostatic and fibrinolytic parameters between healthy dogs and dogs with gastric dilatation and volvulus ...
I. Uhrikova, K. Machackova, L. Rauserova-Lexmaulova, K. Rehakova, J. Doubek   +4 more
doaj   +1 more source

Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and Art Status [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: HIV infection is known to cause coagulation abnormalities by various mechanism, especially during its late course. Aim: The objective of this study is to analyse platelet count, prothrombin time and activated partial thromboplastin time
R Thulasi Raman, D Manimaran, Praveen Rachakatla, K Bharathi, Tameem Afroz, Radha Sagar   +5 more
doaj   +1 more source

Prognostic value of APTT combined with fibrinogen and creatinine in predicting 28-Day mortality in patients with septic shock caused by acute enteric perforation

BMC Surgery, 2023
Background Septic shock is one of the leading causes of mortality in intensive care units. This retrospective study was carried out to evaluate the association of clinical available factors with 28-day mortality. Patients and method In this observational
Shuiqiao Fu, Wenqiao Yu, Qinghui Fu, Zhipeng Xu, Shaoyang Zhang, Ting-bo Liang   +5 more
doaj   +1 more source

Coagulation state monitoring of burn patients in Duhok governorate, Iraq

Indian Journal of Burns
Background and Objective: Patients with severe burns have coagulation abnormalities that are similar to those seen in sepsis or acute trauma patients. Patients with severe burns who experience coagulopathy exhibit abnormalities in procoagulants as well ...
Beri Adil Tawfeq, Bizav Naji Rasheed
doaj   +1 more source

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!

Medicina, 2023
Activated partial thromboplastin time (aPTT) is a fundamental screening test for coagulation disturbances. An increased aPTT ratio is quite common in clinical practice.
Rita Carlotta Santoro, Angelo Claudio Molinari, Marzia Leotta, Tiziano Martini   +3 more
doaj   +1 more source