Results 21 to 30 of about 111,198 (373)
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Nebulized heparin in burn patients with inhalation trauma : safety and feasibility [PDF]
, 2020 Background: Pulmonary hypercoagulopathy is intrinsic to inhalation trauma. Nebulized heparin could theoretically be beneficial in patients with inhalation injury, but current data are conflicting.
Binnekade, Jan M. +17 more
core +2 more sources
Frontiers in Oncology, 2017 Tissue factor (TF)-expressing tumor-derived extracellular vesicles (EVs) can promote metastasis and pre-metastatic niche formation, but the mechanisms by which this occurs remain largely unknown. We hypothesized that generation of activated factor X (FXa)
Sara P. Y. Che +2 more
doaj +1 more source
Influence of vitamin K antagonist treatment on activated partial thromboplastin time [PDF]
, 2015 A
Devreese, Katrien +2 more
core +2 more sources
Canine reference intervals for coagulation markers using the STA Satellite and the STA-R Evolution analyzers [PDF]
, 2010 The aim of the current study was to determine canine reference intervals for prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, and antithrombin (AT) according to international recommendations. The STA Satellite coefficients
Braun, Jean-Pierre +5 more
core +1 more source
Implications of deranged activated partial thromboplastin time for anaesthesia and surgery
Anaesthesia, 2018 Bleeding during and after surgery ranges from trivial to fatal. Bleeding is in part determined by the patient's coagulation status. The UK National Institute for Health and Care Excellence recommends a pre‐operative clotting test for patients with a ...
E. Loizou +3 more
semanticscholar +1 more source
Journal of Clinical Pharmacy and Therapeutics, 2016 The two most common methods for monitoring unfractionated heparin (UFH) infusion are the activated partial thromboplastin time (aPTT) and the antifactor Xa heparin assay (anti‐Xa).
Sophie Samuel +8 more
semanticscholar +1 more source
MOF Coating Enhances the Ion Tolerance of Micromotors
Angewandte Chemie, EarlyView.This work reported a novel method to significantly enhance the ion tolerance of EMNMs using a MOF coating via controllable heteroepitaxial growth, enabling effective motion in high‐salt environments and propulsion through biological tissues under 980 nm NIR light, with potential applications in targeted drug delivery.
Leyan Ou +10 more
wiley +2 more sources
Sensitivity of Thromboplastins [PDF]
Thrombosis and Haemostasis, 1977 Using dilutions 1/1-1/16 of different thromboplastins and undiluted plasma, the prothrombin times were longer with the increase of dilutions. When plasma was diluted in saline or buffer (1/5/1/10), a proportional shortness of the clotting times were observed.
R. Altman, G. Mosquera, J. Rouvier
openaire +1 more source
Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury. [PDF]
, 2017 Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding.
Applegate, Richard +12 more
core +1 more source