Results 81 to 90 of about 7,460 (217)

ITGA2B/ITGB3‐Related Macrothrombocytopenia Associated With Gain‐of‐Function Mutations in ITGA2B or ITGB3 Genes

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Glanzmann thrombasthenia (GT) is an inherited hemorrhagic disorder characterised by impaired platelet functions, manifested clinically as spontaneous bleeding. It is usually inherited in an autosomal recessive manner. Platelet dysfunction in patients with GT is caused by quantitative and/or qualitative deficiencies in αIIbβ3, which result from
Jiao Wu, Han Yan, Zijian Li, Yilin Zhu, Ruonan Shao, Honglei Xin, Tongyu Jia, Mengyu Ge, Lu Zhang, Suyu Jiang, Jianhua Mao, Jiansong Huang, Chao Fang, Xiaodong Xi, Xiaofeng Shi   +14 more
wiley   +1 more source

Association between mean platelet volume and kidney events in patients with type 2 diabetes mellitus

Journal of Diabetes Investigation, Volume 17, Issue 1, Page 51-59, January 2026.
ABSTRACT Introduction Mean platelet volume (MPV), which reflects platelet size and activity, is known to be elevated in patients with type 2 diabetes mellitus. Although increased MPV has been linked to poor glycemic control and diabetic vascular complications, evidence regarding its association with hard kidney outcomes remains limited.
Syuhei Watanabe, Kenichi Tanaka, Hiroshi Kimura, Hirotaka Saito, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama   +7 more
wiley   +1 more source

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network

Pharmaceuticals
Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in immune responses, immunoregulation, and a wide range of physiological and pathological processes.
Miao Huang, Long Wang, Qianhui Zhang, Ling Zhou, Rui Liao, Anguo Wu, Xinle Wang, Jiesi Luo, Feihong Huang, Wenjun Zou, Jianming Wu   +10 more
doaj   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Utility of immature platelet fraction in the Sysmex XN‐1000V for the differential diagnosis of central and peripheral thrombocytopenia in dogs and cats

Journal of Veterinary Internal Medicine
Background The immature platelet fraction (IPF), a parameter obtained by the Sysmex XN‐1000V analyzer, is used in humans to differentiate between central (CEN) and peripheral (PER) thrombocytopenia (TP) but has not been evaluated in small animals ...
Alejandro Perez‐Ecija, Carmen Martinez, Julio Fernandez‐Castañer, Francisco J. Mendoza   +3 more
doaj   +1 more source

Influence of Intravenous Immunoglobulin Treatment on Thrombopoiesis [PDF]

Transfusion Medicine and Hemotherapy, 2012
AIM: The mechanisms by which intravenous immunoglobulins (IVIg) result in an increase in platelet counts in most patients with autoimmune thrombocytopenia (ITP) have not yet been fully explained. One of these mechanisms may be related to stimulation of thrombopoiesis.
Oliver, Meyer, Oliver, Winter, Abdulgabar, Salama   +2 more
openaire   +2 more sources

Platelet volume could predict the efficacy of thrombopoietin receptor agonists in the treatment of patients with primary immune thrombocytopenia

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Decreased platelet production and increased peripheral platelet destruction were two pathological processes in ITP. High MPV could reflect hyper‐productive thrombopoiesis under TPO‐RA treatment. NLR is a marker of immune profile in ITP, it could reflect platelet destruction of platelet.
Bei Xu, Lili Ji, Hao Pang, Luya Cheng, Yanxia Zhan, Pu Chen, Hao Chen, Jie Cheng, Yunfeng Cheng   +8 more
wiley   +1 more source

A patient with glycogen storage disease type Ib presenting with acute myeloid leukemia (AML) bearing monosomy 7 and translocation t(3;8)(q26;q24) after 14 years of treatment with granulocyte colony-stimulating factor (G-CSF): A case report [PDF]

, 2008
Introduction Glycogen storage disease type Ib is an autosomal recessive transmitted disorder of glycogen metabolism caused by mutations in the glucose-6-phosphate translocase gene on chromosome 11q23 and leads to disturbed glycogenolysis as well as ...
Thomas Schroeder, Barbara Hildebrandt, Ertan Mayatepek, Ulrich Germing, Rainer Haas, H Ozen, K Raj, SY Kim, M Pinsk, PJ Simmons, CC Tigue, BP Alter, J Donadieu, PS Rosenberg, EM Sloand, PA Lennon   +15 more
core   +2 more sources

Laboratory Data Analysis of Hemorrhagic Fever With Renal Syndrome Patients to Predict Disease Severity and Patient Prognosis

Journal of Clinical Laboratory Analysis, Volume 39, Issue 23, December 2025.
Prompt access to care with proper treatment is essential for preventing patients from developing renal failure and unfavorable outcomes. This study aimed to elucidate laboratory parameters associated with HFRS severity and prognosis to predict disease course and initiate prompt clinical management.
Hong Shi, Feng Du, Ting Wang, Zhendong Gu, Ting Ruan, Qiujian Zhao, Rui Xu, Yi Wang, Langxi Luo, Shaohua Wang, Liejun Jiang, Yaoni Li   +11 more
wiley   +1 more source

Sub-Cellular Localization of Metalloproteinases in Megakaryocytes

Cells, 2018
Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis.
Alessandro Malara, Daniela Ligi, Christian A. Di Buduo, Ferdinando Mannello, Alessandra Balduini   +4 more
doaj   +1 more source