Results 11 to 20 of about 15,812 (182)
The biology of thrombopoietin and thrombopoietin receptor agonists [PDF]
International Journal of Hematology, 2013 Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. There is no "sensor" of the platelet count; rather TPO is produced in the liver at a constant rate and cleared by TPO receptors on platelets.
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Romiplostim for thrombocytopenia following allogeneic stem cell transplantation: A case series
Hematology/Oncology and Stem Cell Therapy, 2020 Thrombocytopenia is a relatively common complication following allogeneic hematopoietic stem cell transplantation and is associated with increased bleeding, transfusion requirements, chronic graft-versus-host disease, and all-cause mortality.
Guido Lancman +2 more
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Plasma thrombopoietin levels as additional tool in clinical management of thrombocytopenic neonates
Platelets, 2020 Plasma thrombopoietin (Tpo) levels distinguish thrombocytopenia resulting from increased platelet destruction or decreased platelet production. We investigated whether measuring plasma Tpo levels in thrombocytopenic newborns is of diagnostic value to ...
Leendert Porcelijn +5 more
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Pathophysiology, classification, and complications of common asymptomatic thrombocytosis in newborn infants [PDF]
Clinical and Experimental Pediatrics, 2022 We frequently encounter newborn infants with thrombocytosis in the neonatal intensive care unit. However, neonatal thrombocytosis is not yet fully understood.
Ga Won Jeon
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Frontiers in Cell and Developmental Biology, 2022 C3G is a Rap1 guanine nucleotide exchange factor that controls platelet activation, aggregation, and the release of α-granule content. Transgenic expression of C3G in platelets produces a net proangiogenic secretome through the retention of ...
Luis Hernández-Cano +17 more
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Advances in management of pediatric chronic immune thrombocytopenia: a narrative review [PDF]
Journal of Yeungnam Medical Science, 2023 Immune thrombocytopenia (ITP) is a disease in which thrombocytopenia occurs because of immune-mediated platelet destruction and decreased platelet production.
Jae Min Lee
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Asian Journal of Transfusion Science, 2022 INTRODUCTION: Thrombopoietin (TPO) being the major regulator of megakaryopoiesis is expected to show a compensatory increase in immune thrombocytopenia (ITP), however, it is not so observed.
Gurleen Oberoi +5 more
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Clinical Indications for Thrombopoietin and Thrombopoietin-Receptor Agonists [PDF]
Transfusion Medicine and Hemotherapy, 2013 Thrombocytopenia is a common hematologic disorder. Stimulation of thrombopoiesis may reduce the risk for thrombocytopenia-induced bleeding, prevent severe thrombocytopenia, and reduce the need for platelet transfusion. The key cytokine is thrombopoietin (TPO).
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The Thrombopoietin Receptor, MPL, Is a Therapeutic Target of Opportunity in the MPN
Frontiers in Oncology, 2021 The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis share driver mutations that either activate the thrombopoietin receptor, MPL, or indirectly activate it through mutations in the gene for JAK2, its ...
Jerry L. Spivak, Alison R. Moliterno
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Thrombopoietin and platelet aggregation in patients with stable coronary artery disease
Platelets, 2017 Thrombopoietin (TPO) may facilitate platelet activation and aggregation. However, data on the impact of TPO on platelet aggregation in patients with stable coronary artery disease (CAD) are scarce.
Sanne Bøjet Larsen +5 more
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