Results 11 to 20 of about 19,999 (193)

Thrombopoietin-independent generation of platelet-like particles from megakaryoblastic cells. [PDF]

, 2023
The use of megakaryoblastic leukemia MEG-01 cells can help reveal the mechanisms of thrombopoiesis. However, conventional in vitro activation of platelet release from MEG-01 cells requires thrombopoietin, which is costly.
Combes, V, Noulsri, E, Nunthanasup, N, Ketprasit, N, Palasuwan, D, Palasuwan, A, Kulkeaw, K   +6 more
core   +2 more sources

Thrombopoietin Receptor Agonists for Treatment Thrombocytopenia in Dengue Fever [PDF]

, 2023
Dengue fever is considered to be the most prevalent mosquito - borne viral disease worldwide and has proven to be life - threatening at times. Thrombocytopenia occurs in mild and severe cases of dengue fever. commonly observed.
Sisilia, Adelina
core   +2 more sources

Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia. [PDF]

Am J Hematol
ABSTRACT Chronic liver disease (CLD)‐related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD‐related thrombocytopenia who were undergoing elective invasive ...
Han Y, Lin N, Xu J, Wang S, Jin J, Shang J, Xin Y, Tan Y, Zhang D, Hou J, An P, Xie W, Guan Y, Xiong Q, Wu H, Ding H, Chen Y, Li R, Wen Z, Lu M, Yang J, Zhou Z, Zhou Y, Yu Z, Lin K, Wang W, Huang Y, Nan Y, Luo X, Shi R, Kang Y, Han T, Chen S, Wang K, Shan Y, Li J, Liu P, Lu Z, Chen J, Liu Z, Zhang L, Yang L, Sheng J, Zeng Z, Yu Y, Xu X.   +45 more
europepmc   +2 more sources

Regulation of thrombopoietin receptor expression and function [PDF]

, 2004
Of the many cells in the body, the hematopoietic cells are among those with the highest rate of self-renewal and turnover. The production and destruction of these cells are tightly controlled by a number of hematopoietic growth factors, in particular by ...
Coers, Jörn
core   +1 more source

Paraneoplastic thrombocytosis in ovarian cancer [PDF]

, 2012
<p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.</p> <p>Methods: We analyzed clinical data on 619 patients with epithelial ...
Han, H.D., Wang, R., Collins, K., Drew, A.F., Vasquez, H.G., Coward, J., Deavers, M.T., Urbauer, D., Lamkin, D., Matsuo, K., Sood, A.K., Stone, R.L., Lopez-Berestein, G., Bottsford-Miller, J., Shahzad, M.M.K., King, E.R., Mcneish, I.A., Afshar-Kharghan, V., Gershenson, H., Rupairmoole, R., Ahn, E.H., DeGeest, K., Gushiken, F., Tekedereli, I., Ozpolat, B., Nick, A.M., Chiu, W., Armaiz-Pena, G.N., Lutgendorf, S.K., Landen, C.N., Bond, V.K., Balkwill, F., Hu, W., Pecot, C.V.   +33 more
core   +1 more source

Genetic studies of familial myeloproliferative disorders [PDF]

, 2007
Hereditary thrombocythemia (HT) is an autosomal dominant disorder with clinical features resembling sporadic essential thrombocythemia. HT families share similar clinical symptoms caused by heterogeneous genetic alterations.
Liu, Kun
core   +1 more source

Genetic studies of hereditary thrombocythemia [PDF]

, 2013
Hereditary thrombocythemia (HT) is a familial myeloproliferative disorder characterized by an elevated platelet count in peripheral blood. Thrombocytosis is due to a genetic alteration that can be transmitted to the offspring.
Pianta, Annalisa
core   +1 more source

Comparison of Maternal Serum Levels of Thrombopoietin among Pregnant Women with and without Preeclampsia

Kufa Journal for Nursing Sciences, 2020
Background: Preeclampsia is a syndrome and considered one of the most significant causes that can lead to maternal and fetal morbidity and mortality.
Rusul Jabbar Tauma, Zainab H. Al-Kakajy
doaj   +1 more source

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation [PDF]

, 2016
Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN), but the mechanism by which mutant CALR is oncogenic remains unclear.
Schneider, RK, Losman, JA, Perales-Patón, J., Tothova, Z., Peskier, F., Mullally, A., Losman, J.A., Giannini, S, Al-Shahrour, F, Chen, E, Rosen, EA, Chen, E., Al-Shahrour, F., Giannini, S., Ko, A, Elf, S, Abdelfattah, N.S., Wolach, O., Morgan, E.A., Schneider, R.K., Florescu, N, Mullally, A, Elf, S., Florescu, N., Wolach, O, Morgan, EA, Ko, A., Peisker, F, Perales-Patón, J, Tothova, Z, Abdelfattah, NS, Rosen, E.A.   +31 more
core   +1 more source

Plasma thrombopoietin levels as additional tool in clinical management of thrombocytopenic neonates

Platelets, 2020
Plasma thrombopoietin (Tpo) levels distinguish thrombocytopenia resulting from increased platelet destruction or decreased platelet production. We investigated whether measuring plasma Tpo levels in thrombocytopenic newborns is of diagnostic value to ...
Leendert Porcelijn, Elly Huiskes, Laura Onderwater-Van Den Hoogen, Claudia C Folman, Jaap Jan Zwaginga, Masja De Haas   +5 more
doaj   +1 more source