Results 21 to 30 of about 15,812 (182)

A novel recombinant human thrombopoietin for treating prolonged isolated thrombocytopenia after allogeneic stem cell transplantation

Platelets, 2019
Patients with prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) are known to have a poor prognosis. However, there is no standard treatment for PT.
Yu-Qian Sun, Yuan Kong, Xiao-Hui Zhang, Yu Wang, Min-Min Shi, Yang Song, Jun Kong, Hai-Xia Fu, Chen-Hua Yan, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang   +11 more
doaj   +1 more source

Severe Clinical Course in a Patient with Congenital Amegakaryocytic Thrombocytopenia Due to a Missense Mutation of the c-MPL Gene

Turkish Journal of Hematology, 2015
Congenital amegakaryocytic thrombocytopenia (CAMT) generally begins at birth with severe thrombocytopenia and progresses to pancytopenia. It is caused by mutations in the thrombopoietin receptor gene, the myeloproliferative leukemia virus oncogene (c-MPL)
İkbal Ok Bozkaya, Neşe Yaralı, Pamir Işık, Rukiye Ünsal Saç, Betül Tavil, Bahattin Tunç   +5 more
doaj   +1 more source

Development of an Automated Chemiluminescent Enzyme Immunoassay for Measuring Thrombopoietin in Human Plasma

Diagnostics, 2022
Plasma thrombopoietin (TPO) measurements help distinguish between different types of thrombocytopenia but are not feasible in routine clinical practice. We developed a fully automated quantitative chemiluminescent enzyme immunoassay (CLEIA) for measuring
Yukihiro Nishikawa, Shiyo Nishida, Keiko Kuroda, Hirokazu Kashiwagi, Yoshiaki Tomiyama, Masataka Kuwana   +5 more
doaj   +1 more source

D-dencichine Regulates Thrombopoiesis by Promoting Megakaryocyte Adhesion, Migration and Proplatelet Formation

Frontiers in Pharmacology, 2018
Life-threatening chemotherapy-induced thrombocytopenia can increase the risk of bleeding due to a dramatic low platelet count, which may limit or delay treatment schedules in cancer patients. The pressing need for the rapid alleviation of the symptoms of
Shilan Ding, Shilan Ding, Shilan Ding, Shilan Ding, Min Wang, Min Wang, Min Wang, Min Wang, Song Fang, Huibo Xu, Huiting Fan, Yu Tian, Yu Tian, Yu Tian, Yu Tian, Yadong Zhai, Yadong Zhai, Yadong Zhai, Yadong Zhai, Shan Lu, Shan Lu, Shan Lu, Shan Lu, Xin Qi, Fei Wei, Fei Wei, Fei Wei, Fei Wei, Guibo Sun, Guibo Sun, Guibo Sun, Guibo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun   +35 more
doaj   +1 more source

Does diabetes affect paraneoplastic thrombocytosis in colorectal cancer?

Open Medicine, 2022
A large variety of factors can affect colorectal cancer (CRC) survival, including type 2 diabetes mellitus (T2DM) and paraneoplastic thrombocytosis.
Herczeg Gyorgy, Somogyi Aniko, Herold Magdolna, Fodor Agnes, Rosta Klara, Dank Magdolna, Lang Zsolt, Herold Zoltan   +7 more
doaj   +1 more source

Exploring the Burden on Patients Living With and Receiving Treatment for Immune Thrombocytopenia (ITP): Patient and Physician Perceptions From the ITP World Impact Survey (I‐WISh) 2.0

American Journal of Hematology, EarlyView.
ABSTRACT Limited data exist on how patients and physicians perceive immune thrombocytopenia (ITP) symptoms and treatment‐related burden. I‐WISh (ITP World Impact Survey) 2.0 surveyed 1018 patients and 431 physicians in 15 countries to characterize the impact of ITP and its treatments on patients.
Nichola Cooper, James Bussel, Waleed Ghanima, Drew Provan, Yoshiaki Tomiyama, Ming Hou, Donald M. Arnold, Cristina Santoro, Francesco Zaja, Barbara Lovrencic, Mervyn Morgan, Michal Winograd, Jennifer DiRaimo, Danielle Boyle, Olivera Rajkovic‐Hooley, Meritxell Vendranas, Susan Frade, Caroline Kruse   +17 more
wiley   +1 more source

Correction of Thrombocytopenia with Thrombopoietin Receptor Agonists in Patients with Liver Cirrhosis Before Elective Surgery or Invasive Procedures

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to review the pathogenesis of thrombocytopenia and possible ways of its correction in patients with liver cirrhosis before elective surgical interventions or invasive procedures to optimize clinical practice.Key points.
T. A. Deeva, M. V. Maevskaya, V. T. Ivashkin   +2 more
doaj   +1 more source

Thrombopoietin mutation in congenital amegakaryocytic thrombocytopenia treatable with romiplostim

EMBO Molecular Medicine, 2017
Congenital amegakaryocytic thrombocytopenia (CAMT) is an inherited disorder characterized at birth by thrombocytopenia with reduced megakaryocytes, which evolves into generalized bone marrow aplasia during childhood.
Alessandro Pecci, Iman Ragab, Valeria Bozzi, Daniela De Rocco, Serena Barozzi, Tania Giangregorio, Heba Ali, Federica Melazzini, Mohamed Sallam, Caterina Alfano, Annalisa Pastore, Carlo L Balduini, Anna Savoia   +12 more
doaj   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

A new mouse model of thrombopoietin deficiency arising from a spontaneous single base pair mutation

Platelets
Thrombopoietin (TPO) is the principal regulator of bone marrow platelet production and plays an important role in maintaining hematopoietic stem and progenitor cells.
Nan Sophia Han, Emma E. Yvanovich, Shenglin Mei, Harvey G. Roweth, Elisabeth M. Battinelli, David B. Sykes, Ninib Baryawno   +6 more
doaj   +1 more source