Results 31 to 40 of about 15,812 (182)

Intrahospital switch of the P2Y12 inhibitors in patients with ST segment elevation myocardial infarction in ‘real-life’ clinical practice: the effect on the functional activity of thrombocytes and thrombocytopoiesis, prognostic value

Кардиоваскулярная терапия и профилактика, 2019
Aim. To assess the P2Y12 inhibitors switch in patients ST segment elevation myocardial infarction (STEMI) in real-life’ clinical practice, evaluate the functional activity of thrombocytes and thrombocytopoiesis and determine the clinical and prognostic ...
L. I. Malinova, P. V. Dolotovskaya, N. F. Puchinyan, V. V. Furman   +3 more
doaj   +1 more source

Changes in megakaryopoiesis over ontogeny and their implications in health and disease

Platelets, 2020
A growing body of research has made it increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis.
Patricia Davenport, Zhi-Jian Liu, Martha Sola-Visner   +2 more
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Cyclic thrombocytopenia with statistically significant neutrophil oscillations

Clinical Case Reports, 2018
Key Clinical Message Cyclic thrombocytopenia is often misdiagnosed as immune thrombocytopenia due to similar clinical features, a fact of significance because cyclic thrombocytopenia generally responds poorly to treatments used successfully in immune ...
Gabriel P. Langlois, Donald M. Arnold, Jayson Potts, Brian Leber, David C. Dale, Michael C. Mackey   +5 more
doaj   +1 more source

Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia [PDF]

British Journal of Haematology, 2018
SummaryAutoantibodies to thrombopoietin (TPO, also termed THPO) or the TPO receptor (cMpl, also termed MPL) could play a pathological role in immune thrombocytopenia (ITP). In this study, we tested for autoantibodies against TPO, cMpl, or the TPO/cMpl complex in ITP and other thrombocytopenic disorders. Using an inhibition step with excess TPO in fluid‐
Ishac Nazy, John G. Kelton, Jane C. Moore, Rumi Clare, Peter Horsewood, James W. Smith, Nikola Ivetic, Vanessa D'Souza, Na Li, Donald M. Arnold   +9 more
openaire   +2 more sources

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Corticosteroid-dependent chronic immune thrombocytopenic purpura in an 11-year-old child responsive to low-dose rituximab: a case report

Russian Open Medical Journal
Immune thrombocytopenia (ITP) is the most common platelet disorder in children. The peak incidence is observed from 1 to 7 years of age. We report the case of an 11-year-old boy who was diagnosed with ITP four years before visiting our clinic following a
Zainab Omar, Khder Yousf
doaj   +1 more source

New-onset acute thrombocytopenia in hospitalized patients: pathophysiology and diagnostic approach

Journal of Community Hospital Internal Medicine Perspectives, 2017
Thrombocytopenia is a hematological finding commonly encountered in daily clinical practice from asymptomatic clinic patients to critically ill intensive care unit patients.
Naveed Ali, Herbert E. Auerbach
doaj   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source