Results 41 to 50 of about 16,174 (186)

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

Factors associated with venous thromboembolic disease due to failed thromboprophylaxis

Thrombosis Journal, 2023
Introduction Available evidence to identify factors independently associated with failed thromboprophylaxis (FT) in medical patients is insufficient. The present study seeks to evaluate in hospitalized patients, which clinical factors are associated with
Santiago Grillo Pérez, Paula Ruiz-Talero, Oscar Mauricio Muñoz Velandia   +2 more
doaj   +1 more source

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Preoperative versus postoperative initiation of thromboprophylaxis following major orthopedic surgery: safety and efficacy of postoperative administration supported by recent trials of new oral anticoagulants

Thrombosis Journal, 2011
In European countries, low-molecular-weight heparin is generally initiated preoperatively for thromboprophylaxis in hip or knee replacement surgery. The objective of this review is to compare pre- and postoperative thromboprophylaxis strategies using ...
Perka Carsten
doaj   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

What influences women’s decisions to participate in trials for prevention of venous thromboembolism during pregnancy and the puerperium: a qualitative study

BMC Pregnancy and Childbirth
Background Thromboprophlyaxis for the prevention of venous thromboembolism during pregnancy and the puerperium is widespread, but there is a lack of evidence on the risks and benefits of thromboprophylaxis within this population.
Fiona C Sampson, Sarah Davis, Maxine Kuczawski, Rosemary Carser, Beverley J Hunt, Steve Goodacre, Abdullah Pandor, Catherine Nelson-Piercy, Jahnavi Daru   +8 more
doaj   +1 more source

Thromboprophylaxis in nonsurgical patients [PDF]

Hematology, 2012
AbstractVenous thromboembolism (VTE) is an important cause of preventable morbidity and mortality in medically ill patients. Randomized controlled trials indicate that pharmacologic prophylaxis reduces deep venous thrombosis (relative risk [RR] = 0.46; 95% confidence interval [CI], 0.36-0.59) and pulmonary embolism (RR = 0.49; 95% CI, 0.33-0.72) with a
Michael B, Streiff, Brandyn D, Lau
openaire   +2 more sources

Perioperative von Willebrand Factor and Factor VIII Kinetics in von Willebrand Disease Patients Treated With Different Clotting Factor Concentrates

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with von Willebrand disease (VWD) undergoing surgery require von Willebrand factor (VWF) and factor VIII (FVIII) supplementation for adequate haemostasis. Plasma‐derived clotting factor concentrates differ in their VWF:FVIII activity ratios: high‐ratio product (HRP, 10:1), intermediate‐ratio product (IRP, 2.4:1), and low ...
Zoë A. Gras, Geoffrey Z. L. Kuppens, Roger E. G. Schutgens   +2 more
wiley   +1 more source

Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Pregnancy induces significant physiological changes in the hemostatic system, leading to a hypercoagulable state to prevent postpartum hemorrhage. These adaptations involve alterations in coagulation and fibrinolysis, which can be further modified in complicated pregnancies such as gestational diabetes mellitus (GDM) and ...
Yang Su, Yao Wei, Cheng Liu, Yafei Gao, Xiaolong Ma, Yongxin Li, Rui Qiao   +6 more
wiley   +1 more source

Study protocol for the DISTINCT trial: inDividual, targeted thrombosIS prophylaxis versus the standard ‘one-size-fits-all’ approach in patients undergoing Total hIp or total kNee replaCemenT – a national, multicentre, randomised, multiarm, open-label trial

BMJ Open
Introduction Patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) are considered to have a symptomatic venous thromboembolism (VTE) risk of 1.0%–1.5% despite thromboprophylaxis.
Rob G H H Nelissen, Rolf H H Groenwold, Suzanne C Cannegieter, Menno V Huisman, Frederikus A Klok, Wilbert B van den Hout, Leti van Bodegom-Vos, Banne Nemeth, Nienke van Rein, Ruben Y Kok, Harmen B Ettema, Merel van Veen, Stephan B W Vehmeijer, Jan Joost I Wiegerinck   +13 more
doaj   +1 more source