Results 61 to 70 of about 22,851 (227)

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Obstetric Thromboprophylaxis: The Swedish Guidelines

, 2020
Obstetric thromboprophylaxis is difficult. Since 10 years Swedish obstetricians have used a combined risk estimation model and recommendations concerning to whom, at what dose, when, and for how long thromboprophylaxis is to be administrated based on a ...
Margareta Hellgren, Pelle G Lindqvist
core  

Pre- vs. postoperative initiation of thromboprophylaxis in liver surgery [PDF]

, 2021
Background: Thromboprophylaxis protocols in liver surgery vary greatly worldwide. Due to limited research, there is no consensus whether the administration of thromboprophylaxis should be initiated pre-or postoperatively.
Nordin, Arno, Mäkisalo, Heikki, Ainoa, Eppu, Uutela, Aki, Sallinen, Ville   +4 more
core   +1 more source

Study protocol for the DISTINCT trial: inDividual, targeted thrombosIS prophylaxis versus the standard ‘one-size-fits-all’ approach in patients undergoing Total hIp or total kNee replaCemenT – a national, multicentre, randomised, multiarm, open-label trial

BMJ Open
Introduction Patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) are considered to have a symptomatic venous thromboembolism (VTE) risk of 1.0%–1.5% despite thromboprophylaxis.
Rob G H H Nelissen, Rolf H H Groenwold, Suzanne C Cannegieter, Menno V Huisman, Frederikus A Klok, Wilbert B van den Hout, Leti van Bodegom-Vos, Banne Nemeth, Nienke van Rein, Ruben Y Kok, Harmen B Ettema, Merel van Veen, Stephan B W Vehmeijer, Jan Joost I Wiegerinck   +13 more
doaj   +1 more source

Perioperative von Willebrand Factor and Factor VIII Kinetics in von Willebrand Disease Patients Treated With Different Clotting Factor Concentrates

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with von Willebrand disease (VWD) undergoing surgery require von Willebrand factor (VWF) and factor VIII (FVIII) supplementation for adequate haemostasis. Plasma‐derived clotting factor concentrates differ in their VWF:FVIII activity ratios: high‐ratio product (HRP, 10:1), intermediate‐ratio product (IRP, 2.4:1), and low ...
Zoë A. Gras, Geoffrey Z. L. Kuppens, Roger E. G. Schutgens   +2 more
wiley   +1 more source

Postoperative Initiation of Thromboprophylaxis in patients with Cushing’s Disease (PIT-CD): a randomized controlled trial

Trials
Background Pituitary surgical intervention remains the preferred treatment for Cushing’s disease (CD) while postoperative venous thromboembolism (VTE) is a significant risk.
Nidan Qiao, Min He, Zhao Ye, Wei Gong, Zengyi Ma, Yifei Yu, Zhenyu Wu, Lin Lu, Huijuan Zhu, Yong Yao, Zhihong Liao, Haijun Wang, Huiwen Tan, Bowen Cai, Yerong Yu, Ting Lei, Yan Yang, Changzhen Jiang, Xiaofang Yan, Yanying Guo, Yuan Chen, Hongying Ye, Yongfei Wang, Nicholas A. Tritos, Zhaoyun Zhang, Yao Zhao   +25 more
doaj   +1 more source

Perioperative Management in Persons With Haemophilia on Rebalancing Therapies: A Narrative Review

Haemophilia, EarlyView.
ABSTRACT Introduction Perioperative management in haemophilia often requires on‐demand use of clotting factor concentrates (CFC) and/or bypassing agents. Rebalancing agents (fitusiran, concizumab, marstacimab) offer a novel approach to prophylaxis by modulating endogenous anticoagulant pathways to restore haemostatic balance.
Amanda M. Henderson, Roy Khalife, Kelsey Uminski   +2 more
wiley   +1 more source

Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Pregnancy induces significant physiological changes in the hemostatic system, leading to a hypercoagulable state to prevent postpartum hemorrhage. These adaptations involve alterations in coagulation and fibrinolysis, which can be further modified in complicated pregnancies such as gestational diabetes mellitus (GDM) and ...
Yang Su, Yao Wei, Cheng Liu, Yafei Gao, Xiaolong Ma, Yongxin Li, Rui Qiao   +6 more
wiley   +1 more source

Venous Thromboembolism Risk and Adherence to Pharmacological Thromboprophylaxis in Hospitalized Patients in Uruguay: First Nationwide Study

Clinical and Applied Thrombosis/Hemostasis
Introduction Venous thromboembolism (VTE) is a serious, frequent, and preventable medical complication in hospitalized patients. Although the efficacy of prophylaxis (pharmacological and/or mechanical) has been demonstrated, compliance with prophylaxis ...
Valentina Mérola MD, Ana Carina Pizzarossa MD, MSc, Maynés López MD, Franco Peverelli MD, Gustavo Bruno MD, MSc, Mariana González MD, Federico Roca MD, Leticia Dentone MD, Gerardo Pérez MD, Lucía Da Silveira MD, Lilián Díaz MD, Josefina Tafuri MD, Rosario Cuadro MD, Martín Zaquiere MD, Guillermina Bartaburu MD, Franco Pacello MD, Carina Celio MD, María José López MD, Marcelo Viana MD, Laura Fraga MD, Valeria Blanco MD, Paula Chalart MD, Daniel Leal MD, Xilef Rodríguez MD, Laura Teti MD, Carolina Goñi MD, Eduardo Infante MD, Alejandra Prícoli MD, Victoria Altieri MD, Cecilia Guillermo MD, Rosario Martínez MD   +30 more
doaj   +1 more source