Results 41 to 50 of about 5,025 (225)

Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure [PDF]

, 2016
BACKGROUND AND AIMS: Circulating levels of von Willebrand factor (vWF) predict mortality in patients with cirrhosis. We hypothesized that systemic inflammation in acute-on-chronic liver failure (ACLF) will stimulate endothelium, increase vWF levels, and ...
Amirtharaj, GJ, Balasubramanian, KA, Eapen, CE, Elias, E, Goel, A, Mackie, I, Prasanna, KS, Ramachandran, A, Sajith, KG, Zachariah, U   +9 more
core   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli in a renal transplant recipient case report

Brazilian Journal of Nephrology, 2020
Thrombotic microangiopathies are disorders characterized by nonimmune microangiopathic hemolytic anemia, thrombocytopenia, and multi-systemic failure.
John Fredy Nieto-Rios, Monica Zuluaga-Quintero, Julio Cesar Valencia-Maturana, Diana Carolina Bello-Marquez, Arbey Aristizabal-Alzate, Gustavo Adolfo Zuluaga-Valencia, Lina Maria Serna-Higuita, Luis Fernando Arias   +7 more
doaj   +2 more sources

Development of a Novel UPC (Urine Red Blood Cell Distribution, Proteinuria, and Serum Creatinine) Index to Differentiate Glomerular from Nonglomerular Hematuria

Journal of Clinical Laboratory Analysis, EarlyView.
The study developed the UPC index by integrating urine red blood cell distribution (URD), urine protein strip, and serum creatinine to enhance the diagnostic accuracy for distinguishing glomerular from nonglomerular hematuria. The UPC index demonstrated superior performance (AUC 0.857) compared to conventional parameters, showing high sensitivity and ...
Hae In Bang, Sun Min Lee, In Hee Lee, A‐Jin Lee, Chang‐Ho Jeon   +4 more
wiley   +1 more source

Extrarenal manifestations of complement mediated thrombotic microangiopathies

Frontiers in Pediatrics, 2014
Thrombotic microangiopathies (TMA) are rare but severe disorders, characterized by endothelial cell activation and thrombus formation leading to hemolytic anemia, thrombocytopenia and organ failure.
Johannes eHofer, Alejandra eRosales, Caroline eFischer, Thomas eGiner   +3 more
doaj   +1 more source

TTP-like syndrome and its relationship with complement activation in critically ill patients with COVID-19: A cross-sectional study

Heliyon, 2023
Background: The covid-19 disease has caused many deaths worldwide since December 2019. Many thromboembolic events, such as VTE and TTP, have been reported since the beginning of this pandemic.
Mohammadreza Ardalan, Mohammadreza Moslemi, Azin Pakmehr, Sepideh Zununi Vahed, Amirreza Khalaji, Hamidreza Moslemi, Amir Vahedi   +6 more
doaj   +1 more source

Drug-Induced Thrombotic Microangiopathy due to Cumulative Toxicity of Ixazomib

Case Reports in Hematology, 2018
Drug-induced thrombotic microangiopathies (DTMAs) are increasingly being recognized as an important category of thrombotic microangiopathies (TMAs). Cancer therapeutic agents including proteasome inhibitors (PIs) are among the most common medications ...
Suheil Albert Atallah-Yunes, Myat Han Soe   +1 more
doaj   +1 more source

Diclofenac-induced thrombotic thrombocytopenic purpura with concomitant complement dysregulation: a case report and review of the literature

Journal of Medical Case Reports, 2019
Background Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are two forms of thrombotic microangiopathies. They are characterized by severe thrombocytopenia, microangiopathic hemolysis, and thrombosis, leading to a systemic inflammatory ...
Jose Perez Lara, Yaneidy Santana, Maneesh Gaddam, Asghar Ali, Sandeep Malik, Misbahuddin Khaja   +5 more
doaj   +1 more source

Renal dysfunction in symptomatic Waldenström macroglobulinaemia: A nationwide Italian multicentre study

British Journal of Haematology, EarlyView.
Renal dysfunction represents a possible underrecognized complication of symptomatic WM; this condition correlates with adverse global and disease‐specific clinical outcomes. Summary The prognostic significance of impaired renal function in Waldenström macroglobulinaemia (WM) remains poorly defined.
Nicolò Danesin, Francesco Autore, Anna Maria Frustaci, Gianmarco Favrin, Emanuele Cencini, Alessandro Noto, Irene Dogliotti, Jacopo Olivieri, Marcello Riva, Isacco Ferrarini, Anna Maria Barbui, Sara Steffanoni, Dario Marino, Benedetta Puccini, Piero Maria Stefani, Rita Rizzi, Michele Merli, Angela Ferrari, Stefano Luminari, Carlo Visco, Livio Trentin, Andrea Visentin, Annarita Conconi, Simone Ferrero, Marzia Varettoni, Alessandra Tedeschi, Luca Laurenti, Francesco Piazza   +27 more
wiley   +1 more source

The global aHUS registry: methodology and initial patient characteristics [PDF]

, 2015
Background: Atypical hemolytic uremic syndrome (aHUS) is a rare, genetically-mediated systemic disease most often caused by chronic, uncontrolled complement activation that leads to systemic thrombotic microangiopathy (TMA) and renal and other end-organ ...
Ardissino, Gianluigi, Ariceta, Gema, Cohen, David, Cole, J. Alexander, Frémeaux-Bacchi, Véronique, Gasteyger, Christoph, Greenbaum, Larry A., Johnson, Sally, Licht, Christoph, Ogawa, Masayo, Schaefer, Franz, Vande Walle, Johan   +11 more
core   +2 more sources