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Gemcitabine‐induced thrombotic microangiopathy
Internal Medicine Journal, 2013 AbstractThrombotic microangiopathy (TMA) is a microvascular occlusive disorder characterised by platelet aggregation, thrombocytopenia and end‐organ damage. It is commonly idiopathic, although several drug classes, including cytotoxic chemotherapy, have been implicated.
Richmond, J., Gilbar, P., Abro, E.
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New England Journal of Medicine, 2002
The thrombotic microangiopathies (TMA) are a group of diseases associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction. These seemingly disparate entities share in common a pathogenic mechanism involving endothelial injury and thrombus formation.
Daniel, Halevy +3 more
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The thrombotic microangiopathies (TMA) are a group of diseases associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction. These seemingly disparate entities share in common a pathogenic mechanism involving endothelial injury and thrombus formation.
Daniel, Halevy +3 more
+8 more sources
Seminars in Arthritis and Rheumatism, 2014
To review the clinical features and pathophysiologic mechanisms of the thrombotic microangiopathies (TMAs) including acquired and congenital thrombotic thrombocytopenic purpura (TTP), Shiga toxin-induced and atypical (non-Shiga toxin-induced) hemolytic uremic syndrome (HUS), and the TMAs associated with pregnancy, drugs, and organ transplantation ...
M, Starck, C-M, Wendtner
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To review the clinical features and pathophysiologic mechanisms of the thrombotic microangiopathies (TMAs) including acquired and congenital thrombotic thrombocytopenic purpura (TTP), Shiga toxin-induced and atypical (non-Shiga toxin-induced) hemolytic uremic syndrome (HUS), and the TMAs associated with pregnancy, drugs, and organ transplantation ...
M, Starck, C-M, Wendtner
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Thrombotic microangiopathy from Australian brown snake (Pseudonaja) envenoming
Internal Medicine Journal, 2007 Background: Australian brown snake (genus Pseudonaja) envenoming causes a venom-induced consumptive coagulopathy (VICC). A proportion of cases go on to develop thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic haemolytic ...
Paul Lawton, Geoffrey Isbister, G Cull
exaly +2 more sources
Diagnostic dilemma: Severe thrombotic microangiopathy in pregnancy
Journal of the Intensive Care Society, 2017 A diagnostic dilemma occurred when thrombotic microangiopathy developed during pregnancy. The diagnostic criteria of thrombotic microangiopathy include thrombocytopenia (platelets <100) and microangiopathic haemolytic anaemia (including thrombotic ...
Sarah Birkhoelzer +2 more
exaly +2 more sources
European Journal of Internal Medicine, 2000
The term 'thrombotic microangiopathy' (TMA) describes syndromes of microangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organ impairment, due to platelet aggregation in the microcirculation. The term 'hemolytic uremic syndrome' (HUS) has entered clinical use to describe childhood cases of TMA dominated by renal impairment, while ...
, Pisoni, , Remuzzi
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The term 'thrombotic microangiopathy' (TMA) describes syndromes of microangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organ impairment, due to platelet aggregation in the microcirculation. The term 'hemolytic uremic syndrome' (HUS) has entered clinical use to describe childhood cases of TMA dominated by renal impairment, while ...
, Pisoni, , Remuzzi
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A case of thrombotic microangiopathy/microangiopathies
Blood Coagulation & Fibrinolysis, 2014We report a case of Streptococcus pneumonia sepsis-associated disseminated intravascular coagulation (DIC) with features of acute renal failure and microvascular thrombosis characterized by skin purpura and bilateral foot necrosis. The persistence of laboratory features of microangiopathic hemolytic anemia despite aggressive correction of DIC ...
Zhineng J, Yang +2 more
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Thrombotic microangiopathy in pregnancy
Thrombosis Research, 2009Following the initial reports by Moschowitz in 1925 [1] and by Baehr et al. in 1936 [2], Singer [3] and Gasser [4] suggested the terms of “thrombotic thrombocytopenic purpura, TTP” and of “hemolytic uremic syndrome, HUS” to describe related disorders consisting of Coombs’ negative hemolytic anemia, thrombocytopenia, and renal failure.
Armando, D'Angelo +2 more
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Emergency Medicine Clinics of North America
Thrombotic microangiopathies (TMAs) are rare diseases characterized by endothelial injury and microvascular clots. TMAs often lead to microangiopathic hemolytic anemia, thrombocytopenia, and end organ damage. Common TMA types include thrombotic thrombocytopenic purpura (TTP), infection-associated hemolytic uremic syndrome, and complement-mediated TMAs.
Ramy, Hanna +2 more
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Thrombotic microangiopathies (TMAs) are rare diseases characterized by endothelial injury and microvascular clots. TMAs often lead to microangiopathic hemolytic anemia, thrombocytopenia, and end organ damage. Common TMA types include thrombotic thrombocytopenic purpura (TTP), infection-associated hemolytic uremic syndrome, and complement-mediated TMAs.
Ramy, Hanna +2 more
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Syndromes of Thrombotic Microangiopathy
Medical Clinics of North America, 2017Thrombotic thrombocytopenia purpura (TTP) and the hemolytic uremic syndrome (HUS) are rare thrombotic microangiopathies that can be rapidly fatal. Although the acquired versions of TTP and HUS are generally highest on this broad differential, multiple rarer entities can produce a clinical picture similar to TTP/HUS, including microangiopathic hemolysis,
Joseph J, Shatzel, Jason A, Taylor
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