Results 101 to 110 of about 51,562 (315)
Applied Research, Volume 4, Issue 3, June 2025.The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury +9 more
wiley +1 more source
Infection and Drug Resistance, 2023 Fei Lv,1,2 Yue Zhao,2 Xing-Di Yang,2 Han-Zhu Chen,2 Wen-Ya Ren,2 Ling-Xia Chen,2 Qiao-Qiao Yi,2 Wei Zheng,2 Hong-Ying Pan2 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China ...
Lv F +8 more
doaj
Journal of Venomous Animals and Toxins including Tropical Diseases, 2014 Hump-nosed viper bites are frequent in southern India and Sri Lanka. However, the published literature on this snakebite is limited and its venom composition is not well characterized.
Milinda Withana +3 more
doaj +1 more source
Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]
, 2009 Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor +10 more
core +1 more source
Case Reports in Medicine, 2014 Introduction. Sunitinib malate is an oral multitargeting tyrosine kinase inhibitor approved for the first line treatment of metastatic renal cell carcinoma.
Imane El Dika +4 more
doaj +1 more source
Autoimmune thrombotic thrombocytopenic purpura (TTP) associated with COVID-19
Annals of Hematology, 2020 Dear Editor: A 57-year-old woman with a history of hypertension and breast cancer in complete remission was seen in lateMarch 2020 at the emergency ward in a private clinic with dry cough, anosmia, and dysgeusia.
N. Albiol, R. Awol, R. Martino
semanticscholar +1 more source
Statistically adaptive learning for a general class of cost functions (SA L-BFGS) [PDF]
arXiv, 2012 We present a system that enables rapid model experimentation for tera-scale machine learning with trillions of non-zero features, billions of training examples, and millions of parameters. Our contribution to the literature is a new method (SA L-BFGS) for changing batch L-BFGS to perform in near real-time by using statistical tools to balance the ...
arxiv
Mathematical model of SARS-Cov-2 propagation versus ACE2 fits COVID-19 lethality across age and sex and predicts that of SARS, supporting possible therapy [PDF]
arXiv, 2020 The fatality rate of Covid-19 escalates with age and is larger in men than women. I show that these variations correlate strongly with the level of the viral receptor protein ACE2 in rat lungs, which is consistent with the still limited and apparently contradictory data on human ACE2.
arxiv
Caplacizumab Therapy without Plasma Exchange for Acquired Thrombotic Thrombocytopenic Purpura.
New England Journal of Medicine, 2019 Managing Acquired TTP without Plasma Exchange A case of acquired thrombotic thrombocytopenic purpura is reported in a Jehovah’s Witness who had neurologic manifestations but would not accept plasma...
Deepak P. Chander +3 more
semanticscholar +1 more source
Cerebral fat embolism syndrome mimicking thrombotic thrombocytopenic purpura in a patient with Hemoglobin SC disease [PDF]
, 2016 Case Presentation A 54 year‐old man with hemoglobin SC disease (HbSC) and a history of substance abuse presented to the Emergency Department from a nursing home with two days of progressive weakness, shortness of breath, and lower back pain.
Devnani, Rohit +2 more
core +1 more source