Results 71 to 80 of about 52,108 (298)

Daratumumab for immune thrombotic thrombocytopenic purpura

Blood Advances, 2021
Key Points Treatment of iTTP with daratumumab leads to disappearance of ADAMTS13 inhibitor and restoration of normal ADAMTS13 activity. Targeting of plasma cells with daratumumab is a new treatment option in relapsing and refractory iTTP.
J. van den Berg, J. K. Kremer Hovinga, C. Pfleger, I. Hegemann, G. Stehle, A. Holbro, J. Studt   +6 more
semanticscholar   +1 more source

Contrasting Approaches in the Implementation of GRADE Methodology in Guidelines for Haemophilia and Von Willebrand Disease

Haemophilia, EarlyView.
ABSTRACT Introduction The 2024 ISTH clinical practice guideline (CPG) for treatment of congenital haemophilia, the NBDF‐McMaster Guideline on Care Models for Haemophilia Management, and ASH ISTH NBDF WFH guidelines on the diagnosis and management of VWD all utilised GRADE methodology.
Mark W. Skinner, Manuela Albisetti, Jesús Ardila, Jan Astermark, Jan Blatny, Manuel Carcao, Pratima Chowdary, Nathan T. Connell, Miguel Crato, Yesim Dargaud, Roseline d'Oiron, Amy L. Dunn, Miguel A. Escobar, Carmen Escuriola‐Ettingshausen, Emna Gouider, Annie Harroche, Cedric Hermans, Victor Jimenez‐Yuste, Radoslaw Kaczmarek, Gili Kenet, Liane Khoo, Robert Klamroth, Florian Langer, David Lillicrap, Johnny Mahlangu, Christoph Male, Tadashi Matsushita, Sandrine Meunier, Wolfgang Miesbach, Beatrice Nolan, Johannes Oldenburg, Brian O'Mahony, Margareth Ozelo, Glenn F. Pierce, Gloria Ramos, Michael Recht, Olivia Romero‐Lux, Dawn Rotellini, Rita C. Santoro, Tammuella C. Singleton, Alok Srivastava, Sophie Susen, Kate Talks, Huyen Tran, Leonard A. Valentino, Jerzy Windyga, Renchi Yang, Maria Elisa Mancuso, also on behalf of AICE, AHAD‐AP, AHCDC, ATHN, CLAHT, EHC, French CRH & MHEMO, HTCCNC, NBDF, PEDNET, UKHCDO, WFH   +59 more
wiley   +1 more source

Thrombotic microangiopathy and associated renal disorders [PDF]

, 2012
Thrombotic microangiopathy (TMA) is a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion.
Barbour, T, Cohney, S, Hughes, P, Johnson, S   +3 more
core   +1 more source

Plasma levels of S100A8/A9, histone/DNA complexes, and cell‐free DNA predict adverse outcomes of immune thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2020
Immune thrombotic thrombocytopenic purpura (iTTP) is a life‐threatening blood disorder, primarily resulting from autoantibodies against ADAMTS13. Infection or inflammation often precedes acute iTTP.
Jingrui Sui, Ruinan Lu, Konstantine Halkidis, N. K. Kocher, W. Cao, Marisa B. Marques, X. L. Zheng   +6 more
semanticscholar   +1 more source

Co‐Occurrence of HIV‐Susceptibility and ‐Protective HLA Alleles Is a Possible Contributor to the Development of Primary HIV‐Associated Thrombocytopenia (PHAT): A Cross‐Sectional Study

International Journal of Immunogenetics, EarlyView.
ABSTRACT Primary HIV‐associated thrombocytopenia (PHAT) is an isolated thrombocytopenia in HIV‐positive individuals in the absence of secondary causes. The presence of certain Human Leukocyte Antigens (HLA) has been linked to individuals’ immune response to HIV and the development of immune‐mediated thrombocytopenic disorders.
Walter J Janse van Rensburg, Anne‐Cecilia van Marle, Lomari Geertsema   +2 more
wiley   +1 more source

Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP) [PDF]

Documenta Haematologica
We report two cases of recurrent thrombotic thrombocytopenic purpura, both patients without significant personal pathological antecedents, in which the evolution was favorable following the association of Caplacizumab with the classic treatment with ...
Mihaela-Sabrina HERDEA, Adela-Sara IONESCU, Oana PATRINOIU, Mihaela ANDREESCU   +3 more
doaj   +1 more source

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura.

Blood, 2018
Preemptive rituximab infusions prevent relapses in immune thrombotic thrombocytopenic purpura (iTTP) by maintaining normal ADAMTS13 activity. However, the long-term outcome of these patients and the potential adverse events of this strategy need to be ...
M. Jestin, Y. Benhamou, A. Schelpe, E. Roose, F. Provôt, L. Galicier, M. Hié, C. Presne, P. Poullin, A. Wynckel, S. Saheb, C. Deligny, A. Servais, S. Girault, Yahsou Delmas, T. Kanouni, A. Lautrette, D. Chauveau, C. Mousson, P. Pérez, J. Halimi, A. Charvet-Rumpler, M. Hamidou, P. Cathébras, K. Vanhoorelbeke, A. Veyradier, P. Coppo   +26 more
semanticscholar   +1 more source

Success and limitations of plasma treatment in pregnant women with congenital thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2020
Congenital thrombotic thrombocytopenic purpura (cTTP), otherwise known as Upshaw‐Schulman syndrome, is an extremely rare hereditary disease. Pregnancy is identified as a trigger for TTP episodes in patients with cTTP.
K. Sakai, Y. Fujimura, Yasuyuki Nagata, S. Higasa, M. Moriyama, A. Isonishi, M. Konno, M. Kajiwara, Y. Ogawa, Shigehiko Kaburagi, T. Hara, K. Kokame, T. Miyata, K. Hatakeyama, M. Matsumoto   +14 more
semanticscholar   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Thrombotic Thrombocytopenic Purpura Revisited: Upshaw Schulman Syndrome in a 20-Year-Old Male [PDF]

, 2012
Case Report A 20-year-old male with no significant past medical history presented to an outside hospital with a two-week history of progressive fatigue, malaise and decreased appetite. Prior to these events, he had been in his usual state of health with
Peiris, MD, Niluk, Wang, MD, Judy
core   +2 more sources