Results 1 to 10 of about 1,598,447 (336)
High-Throughput Glycomic Methods
Chemical Reviews, 2022 Glycomics aims to identify the structure and function of the glycome, the complete set of oligosaccharides (glycans), produced in a given cell or organism, as well as to identify genes and other factors that govern glycosylation. This challenging endeavor requires highly robust, sensitive, and potentially automatable analytical technologies for the ...
Irena Trbojević-Akmačić +2 more
exaly +5 more sources
SLAS Technology, 2023 Laboratory automation uses large amounts of plastic consumables, generating substantial single-use plastic waste. Automated ELISAs are an indispensable analytical tool in vaccine formulation and process development.
Brittney Pedrazzi +7 more
doaj +1 more source
A perspective on the discovery of enzyme activators
SLAS Discovery, 2022 Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville +4 more
doaj +1 more source
Navigating the Landscape: A Comprehensive Review of Current Virus Databases
Viruses, 2023 Viruses are abundant and diverse entities that have important roles in public health, ecology, and agriculture. The identification and surveillance of viruses rely on an understanding of their genome organization, sequences, and replication strategy ...
Muriel Ritsch +3 more
doaj +1 more source
EndoBind detects endogenous protein-protein interactions in real time
Communications Biology, 2021 Bill et al describe two high-throughput methods to detect protein-protein interactions in cells in real-time using the split-NanoLuciferase-complementation system.
Anke Bill +12 more
doaj +1 more source
High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ
SLAS Discovery, 2023 The cellular thermal shift assay (CETSA®) has increasingly been used in early drug discovery to provide a measure of cellular target engagement. Traditionally, CETSA has been employed for bespoke questions with small to medium throughput and has ...
Hannah Rowlands +9 more
doaj +1 more source
Decoding cell-type contributions to the cfRNA transcriptomic landscape of liver cancer
Human Genomics, 2023 Background Liquid biopsy, particularly cell-free RNA (cfRNA), has emerged as a promising non-invasive diagnostic tool for various diseases, including cancer, due to its accessibility and the wealth of information it provides.
Aram Safrastyan +2 more
doaj +1 more source
A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa
Microbiology Spectrum, 2022 Pseudomonas aeruginosa is an opportunistic pathogen that has been declared by the World Health Organization as a “priority 1 critical pathogen” needing immediate new strategies for chemotherapy. During infection, P.
Mamie Kannon +5 more
doaj +1 more source
High-throughput transcriptomics
Scientific Reports, 2022 High-throughput transcriptomics has revolutionised the field of transcriptome research by offering a cost-effective and powerful screening tool. Standard bulk RNA sequencing (RNA-Seq) enables characterisation of the average expression profiles for individual samples and facilitates identification of the molecular functions associated with genes ...
Nunzio D’Agostino +2 more
openaire +4 more sources
Sensing-Throughput Tradeoff for Interweave Cognitive Radio System: A Deployment-Centric Viewpoint [PDF]
, 2015 Secondary access to the licensed spectrum is viable only if interference is avoided at the primary system. In this regard, different paradigms have been conceptualized in the existing literature.
Chatzinotas, Symeon +4 more
core +3 more sources