Results 41 to 50 of about 5,417 (255)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The Journal of Engineering, 2014 Simple, low-cost and stable passive Q-switched thulium-doped fibre lasers (TDFLs) operating at 1892.4 and 1910.8 nm are demonstrated using 802 and 1552 nm pumping schemes, respectively, in conjunction with a multi-walled carbon nanotubes (MWCNTs ...
Norazlina Saidin +8 more
doaj +1 more source
Deep Laser Cooling of Thulium Atoms to Sub-µK Temperatures in Magneto-Optical Trap
Atoms, 2023 Deep laser cooling of atoms, ions, and molecules facilitates the study of fundamental physics as well as applied research. In this work, we report on the narrow-line laser cooling of thulium atoms at the wavelength of 506.2nm with the natural linewidth ...
Daniil Provorchenko +8 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Dynamics of Multi-Peak Pulsed Generation in a Q-Switched Thulium-Doped Fiber Laser
Photonics, 2022 We demonstrate a detailed theoretical and experimental study of a thulium-doped fiber laser being Q-switched by means of an acousto-optic modulator. The processes leading to the generation of discontinuous multi-peak pulses with an energy of up to 5 μJ ...
Alisa E. Fale +8 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Journal of Functional BiomaterialsNanoparticle-based X-ray radiosensitization strategies have garnered significant attention in recent years. However, the underlying mechanisms of radiosensitization remain incompletely understood.
Xiang Zhu +7 more
doaj +1 more source
Electronic Shielding by Closed Shells in Thulium Compounds [PDF]
, 1964 NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. The Mossbauer effect has been used to investigate electronic shielding by closed electron shells in salts of trivalent thulium, by ...
Poindexter, John Marlan. +1 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source