Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]
, 2017 The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a
Beyaert, Rudi +14 more
core +3 more sources
Ultrastructural analysis of changes in neurons of the mouse internal anal sphincter during ageing [PDF]
, 2013 Gastrointestinal disorders, including chronic constipation, faecal impaction and incontinence, are a major cause of morbidity in the ...
Colyer, Frances +5 more
core
Androgen receptors beyond prostate cancer: an old marker as a new target. [PDF]
, 2014 Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy.
Kurzrock, Razelle +2 more
core +2 more sources
Thoracic Cancer, 2019 Background Anterior mediastinal lesions account for approximately half of all mediastinal masses and computed tomography (CT) is known to exhibit limited differentiating performance.
Ju Gang Nam +5 more
doaj +1 more source
Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]
, 2016 Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo +14 more
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Thymic Carcinoma which Developed in a Thymic Cyst.
Internal Medicine, 1996 Thymic carcinoma was found in a thymic cyst in a 60-year-old woman who was admitted to our hospital due to cough and pain in her right chest. Chest X-ray showed a huge shadow in the right mediastinum. Chest CT scan showed a cystic tumor with a solid mass. An operation revealed a solid tumor in the thymic cyst.
S, Yamashita +5 more
openaire +3 more sources
EVALUATING THE THERAPEUTIC EFFICACY OF RESTORING WILD-TYPE P53 ACTIVITY IN P53-MUTANT TUMORS [PDF]
, 2017 The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, TP53 mutations have been shown to be remarkably predictive of refractoriness to treatment,
Larsson, Connie A
core +1 more source
Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice [PDF]
, 2013 Incontinence and sexual dysfunction are often increased in the aged human population. In rats and mice the pattern of micturition and faecal clearance also changes with ageing and is suggestive of bladder and bowel ...
Black, G. +4 more
core
Radiotherapy for Thymic Carcinoma: Adjuvant, Inductive, and Definitive
Frontiers in Oncology, 2014 Although historically thymoma and thymic carcinoma have been treated surgically, radiation therapy also has an important role, either as postoperative therapy to reduce the risk of mediastinal recurrence or as part of definitive treatment for patients ...
Ritsuko eKomaki, Daniel eGomez
doaj +1 more source
Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy [PDF]
, 2012 The thymus is a central lymphoid organ with crucial role in generating T cells and maintaining homeostasis of the immune system. More than 30 peptides, initially referred to as “thymic hormones,” are produced by this gland.
A Billich +121 more
core +1 more source