Results 81 to 90 of about 39,839 (224)

Durable Response to Lenvatinib in Platinum-Refractory Metastatic High-Grade Thymic Mucoepidermoid Carcinoma: A Case Report

JTO Clinical and Research Reports
Thymic mucoepidermoid carcinoma (MEC) is a rare thymic carcinoma subtype. Current metastatic thymic carcinoma guidelines recommend first-line platinum-based chemotherapy.
Noa Amin, PhD, MRCP, Thanika Ketpueak, DM, Simon Jordan, MBBCh, MD, Andrew G. Nicholson, DM, FRCPath, Yu Zhi Zhang, MBBS, PhD, FRCPath, Sanjay Popat, PhD FRCP   +5 more
doaj   +1 more source

Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. [PDF]

, 1987
After culture in IL-2, thymocytes expressing either TCR-alpha/beta or -gamma/delta acquired the ability to lyse hematopoietic and solid tumor cell targets without deliberate immunization or apparent restriction by the MHC.
Gemlo, BT, Lanier, LL, Phillips, JH, Rayner, AA, Weiss, A   +4 more
core   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Evaluation of anterior mediastinal solid tumors by CT perfusion: a preliminary study

Diagnostic and Interventional Radiology, 2017
PURPOSE:We aimed to assess the role of computed tomography (CT) perfusion in differentiation of thymoma from thymic hyperplasia, lymphoma, thymic carcinoma, and lung cancer invading anterior mediastinum.METHODS:In this study, 25 patients with an anterior
Selim Bakan, Sedat Giray Kandemirli, Atilla Süleyman Dikici, Ezel Erşen, Onur Yıldırım, Cesur Samancı, Şebnem Batur, Deniz Çebi Olgun, Fatih Kantarcı, Canan Akman   +9 more
doaj   +1 more source

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

Cystic cervical thymoma in a cat

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 12‐year‐old, female, neutered Persian cat was presented with a 4‐month history of a progressively enlarging, soft, fluctuating, ventral cervical mass that intermittently caused dysphagia and coughing. Repeated aspiration temporarily reduced the swelling.
Rachel L. Nixon, Andreu Masdefiol Garriga, Sophie Griffin, Dario Costanza, Kathryn M. Pratschke   +4 more
wiley   +1 more source

Surgical therapy of thymic tumours with pleural involvement: an ESTS Thymic Working Group Project [PDF]

, 2017
OBJECTIVES Surgery for thymic epithelial tumours (TETs) with pleural involvement is infrequently performed. Thus, the value of surgical therapy for primary or recurrent TETs with pleural involvement is not sufficiently defined yet.
Bille, Andrea, Brioude, Geoffrey, de Antonio, David Gómez, de Perrot, Marc, Fabre, Dominique, Fadel, Elie, Guerrera, Francesco, Janik, Stefan, Jungraithmayr, Wolfgang, Keshavjee, Shaf, Klepetko, Walter, Lang-Lazdunski, Loic, Liberman, Moishe, Moser, Bernhard, Novoa, Nuria, Ruffini, Enrico, Scarci, Marco, Thomas, Pascal, Van Raemdonck, Dirk, Viskens, Sophie, Weder, Walter   +20 more
core   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Myasthenia Gravis Related to Thymic Carcinoma: A Case Study

The Thoracic & Cardiovascular Surgeon Reports, 2020
Myasthenia gravis and thymoma are often presented in association with ∼10% of myasthenic cases having concomitant thymoma. Thymic carcinoma is one of the rarest/aggressive human epithelial tumors and has no correlation with myasthenia gravis hitherto ...
Daniel Thomas Pereira Lopes, Samila Marissa Pinheiro Gomes, Sheila Aparecida Coelho Siqueira, Fernando Pereira Frassetto, Pedro Henrique Martins Arruda Sampaio, Cristiane Araujo Martins Moreno, Maria Sheila Guimarães Rocha, Eduardo Paula Estephan   +7 more
doaj   +1 more source