Results 51 to 60 of about 624,402 (215)

Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh [PDF]

, 2009
The aim was to assess the impact of nutritional status and environmental exposures on infant thymic development in the rural Matlab region of Bangladesh.
Collinson, A. C.,, Collinson, AC, Prentice, AM, Vahter, M.,, Raqib, R, Arifeen, SE, R Raqib, Prentice, A. M.,, SE Moore, Prentice, A M, SE Arifeen, Fulford, AJC, Moore, SE, Moore, Sophie E, AC Collinson, Arifeen, S E, Vahter, M, Y Wagatsuma, Raqib, R.,, Persson, L A, Arifeen, S. E.,, Wagatsuma, Y.,, AJC Fulford, Moore, Sophie E.,, Vahter, M,, Fulford, A J C, Persson, LA, AM Prentice, LÅ Persson, Moore, Sophie E; id_orcid, Fulford, A. J. C.,, Collinson, A C, Persson, Lars-Åke,, Wagatsuma, Y, M Vahter   +34 more
core   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Jeker, LT, Lei, Y., Jeker, L. T., Lei, Y, Georg A. Holländer, Ishimaru, N, Holländer, GA, Bösl, MR, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Malefyt, RW, Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Takahama, Y, Nagasawa, T., Nitta, T, Nagasawa, T, Izumi Ohigashi, Ripen, A. M., Hayashi, Y, Ohigashi, I., Malefyt, R. D., Takashi Nagasawa, Malefyt Rde, W., Ohigashi, I, Ripen, AM, Adiratna Mat Ripen   +36 more
core   +1 more source

The challenges in diagnosis of thymic carcinoma [PDF]

, 2022
Thymic Carcinoma (TC) is a rare tumor among the epithelial tumors of the thymus with a challenging diagnosis for pathologists. A case report, a 55-year-old male patient complained of coughing, chest pain, and intermittent shortness of breath for 2 weeks ...
Kusumastuti, E. H. (Etty), Sugianto, Yenny Meilany, Sugianto, Y. M. (Yenny), Kusumastuti, Etty Hary   +3 more
core   +1 more source

Thymic Carcinoma which Developed in a Thymic Cyst.

Internal Medicine, 1996
Thymic carcinoma was found in a thymic cyst in a 60-year-old woman who was admitted to our hospital due to cough and pain in her right chest. Chest X-ray showed a huge shadow in the right mediastinum. Chest CT scan showed a cystic tumor with a solid mass. An operation revealed a solid tumor in the thymic cyst.
YAMASHITA, Shu-ichi, YAMAZAKI, Hiroshi, KATO, Tatsuji, YOKOTA, Tada-aki, MATSUMOTO, Nobuhiro, MATSUKURA, Shigeru   +5 more
openaire   +3 more sources

Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]

, 2014
Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Rapid imaging of thymoma and thymic carcinoma with a fluorogenic probe targeting γ-glutamyltranspeptidase

Scientific Reports, 2023
In recent years, thoracoscopic and robotic surgical procedures have increasingly replaced median sternotomy for thymoma and thymic carcinoma. In cases of partial thymectomy, the prognosis is greatly improved by ensuring a sufficient margin from the tumor,
Daisuke Yoshida, Mako Kamiya, Shun Kawashima, Takafusa Yoshioka, Haruaki Hino, Atsuki Abe, Kyohhei Fujita, Ryosuke Kojima, Aya Shinozaki-Ushiku, Yasuteru Urano, Jun Nakajima   +10 more
doaj   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source