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Expression and Regulation of Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin Receptor Heterocomplex in the Innate–Adaptive Immunity of Pediatric Asthma [PDF]

open access: yesInternational Journal of Molecular Sciences, 2018
Asthma is a chronic inflammatory disease affecting the airway, and it is characterized by a wheezing breathing sound, variable airflow obstruction and the presence of inflammatory cells in the submucosa of the bronchi. Viral infection, pollutants and sensitivity to aeroallergens damage the epithelium from childhood, which causes asthma.
Junjen Liu, Sheng-Chieh Lin
exaly   +3 more sources
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Overexpression of thymic stromal lymphopoietin in allergic rhinitis

Acta Oto-Laryngologica, 2009
Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR.To evaluate the possible role of TSLP in the pathogenesis of AR.We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link ...
Guoqiang Zhao, Jiahong Xia, Huabin Li
exaly   +3 more sources

Thymic stromal lymphopoietin is regulated by the intracellular calcium

Cytokine, 2012
The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic diseases such as atopic dermatitis. However, it has not been clarified that TSLP would be regulated by intracellular calcium in mast cells yet.
Na-Ra, Han   +2 more
openaire   +2 more sources

Value of thymic stromal lymphopoietin as a biomarker in children with asthma

Respiratory Medicine, 2022
Thymic stromal lymphopoietin (TSLP), an epithelium-derived pro-inflammatory cytokine, activates distinct immune and non-immune cells. It has been shown to be a master regulator of type 2 immune responses. Limited information is available on TSLP in childhood asthma.
Renata Vrsalović   +6 more
openaire   +2 more sources

The suppression of thymic stromal lymphopoietin expression by selenium

Amino Acids, 2011
Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis. Selenium (Se) has various effects such as antioxidant, antitumor, antiulcer, and anti-inflammatory effects. However, the effect of Se on the production of TSLP has not been clarified. Thus, we investigated how Se inhibits
Phil-Dong, Moon, Hyung-Min, Kim
openaire   +2 more sources

Regulators of thymic stromal lymphopoietin production by human adipocytes

Cytokine, 2020
Thymic stromal lymphopoietin (TSLP) is a cytokine that is known to play a role in inflammatory conditions, especially asthma and atopic dermatitis. It is also recognized to be expressed in human adipose tissue. TSLP production from human adipocytes is stimulated by thyroid-stimulating hormone (TSH).
Loretta, Ma   +2 more
openaire   +2 more sources

Role of Thymic Stromal Lymphopoietin in the Pathogenesis of Nasal Polyposis

American Journal of the Medical Sciences, 2011
Polyposis is an end form of chronic mucosal inflammation in a number of disorders and has an important impact on patient's life quality. Thymic stromal lymphopoietin (TSLP) is involved in many inflammatory processes such as asthma and allergic rhinitis (AR).

exaly   +3 more sources

Thymic stromal lymphopoietin and atopic diseases

Revue Française d'Allergologie, 2014
Abstract Studies from the last ten years have seen great progress in recognizing the role of cytokine thymic stromal lymphopoietin (TSLP) in pathogenesis of atopic diseases, particularly atopic dermatitis (AD) and asthma. We provide here a review of the findings from four aspects: (1) TSLP: expression triggers and cellular sources; (2) TSLP receptor:
Leyva-Castillo, J.M., Li, M.
openaire   +1 more source

Therapy Directed Against Thymic Stromal Lymphopoietin

Drug News & Perspectives, 2008
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine and has been shown to be one of the factors released by epithelial cells following allergen contact with an important role instructing dendritic cells (DCs) to induce a T-helper type 2 (Th2) response.
openaire   +2 more sources

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