Results 151 to 160 of about 10,319 (186)
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Thymic stromal lymphopoietin and atopic diseases
Revue Française d'Allergologie, 2014Abstract Studies from the last ten years have seen great progress in recognizing the role of cytokine thymic stromal lymphopoietin (TSLP) in pathogenesis of atopic diseases, particularly atopic dermatitis (AD) and asthma. We provide here a review of the findings from four aspects: (1) TSLP: expression triggers and cellular sources; (2) TSLP receptor:
Leyva-Castillo, J.M., Li, M.
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The role of thymic stromal lymphopoietin in cutaneous disorders
Archives of Dermatological ResearchThymic Stromal Lymphopoietin (TSLP) is an important cytokine that invokes early immune responses. TSLP, an IL-7-like cytokine encoded by the TSLP gene, activates JAK1 and JAK2 signaling pathways, stimulating dendritic cells to induce inflammatory Th2 cells.
Alexander J. Jafari +2 more
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Therapy Directed Against Thymic Stromal Lymphopoietin
Drug News & Perspectives, 2008Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine and has been shown to be one of the factors released by epithelial cells following allergen contact with an important role instructing dendritic cells (DCs) to induce a T-helper type 2 (Th2) response.
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The Regulation of Thymic Stromal Lymphopoietin in Gut Immune Homeostasis
Digestive Diseases and Sciences, 2011Thymic stromal lymphopoietin is a novel IL-7-like cytokine that exerts immunomodulatory effects and is constitutively expressed by intestinal epithelial cells in response to commensal bacteria colonization. Thymic stromal lymphopoietin can directly or indirectly promote Th2 and Treg responses, and is believed to inhibit Th1 and Th17 responses and limit
Ming, Li +3 more
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Thymic stromal lymphopoietin is present in human breast milk
Pediatric Allergy and Immunology, 2010Macfarlane TV, Seager AL, Moller M, Morgan G, Thornton CA. Thymic stromal lymphopoietin (TSLP) is present in human breast milk. Pediatr Allergy Immunol 2010: 21: e454–e456. © 2010 The Authors Journal compilation © 2010 Blackwell MunksgaardThymic stromal lymphopoietin (TSLP) has emerged as a potential key mediator of both the initiation and maintenance ...
Trisha V, Macfarlane +4 more
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Functions of thymic stromal lymphopoietin in non-allergic diseases
Cellular Immunology, 2015Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine produced mainly by epithelial cells. Many studies indicate that TSLP contributes to promote T helper (Th) 2 immune responses which are associated with the pathogenesis of allergic inflammatory diseases.
Guoqing, Ying +3 more
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Role of Thymic Stromal Lymphopoietin in the Pathogenesis of Nasal Polyposis
The American Journal of the Medical Sciences, 2011Polyposis is an end form of chronic mucosal inflammation in a number of disorders and has an important impact on patient's life quality. Thymic stromal lymphopoietin (TSLP) is involved in many inflammatory processes such as asthma and allergic rhinitis (AR).
Tao, Liu +8 more
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Thymic stromal lymphopoietin: a central regulator of allergic asthma
Expert Opinion on Therapeutic Targets, 2014Epithelial cell-derived mediators have emerged as key players for instigating local remodeling and the associated cellular inflammation in asthmatic airways. In particular, the epithelial-derived cytokine, thymic stromal lymphopoietin (TSLP), has been identified as a master switch for allergic inflammation.TSLP is expressed by structural and immune ...
Brittany, Watson, Gail M, Gauvreau
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Thymic Stromal Lymphopoietin (TSLP)
Science-Business eXchange, 2013Steven F. Ziegler +5 more
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