Results 151 to 160 of about 21,196 (261)
Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 25-55, February 2026.ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology +4 more
wiley +1 more source
TSLP is involved in expansion of early thymocyte progenitors
BMC Immunology, 2007 Background Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
Coffield V McNeil +3 more
doaj +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 124-135, February 2026.ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu +7 more
wiley +1 more source
Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
Allergy, Volume 81, Issue 2, Page 480-497, February 2026.This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino +12 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2022 Yu-qing Hu, Jian-zhong Zhang Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic ChinaCorrespondence: Jian-zhong Zhang, Tel +86-10-88325472, Fax +86-10-68318386, Email rmzjz@126.comBackground: Bullous pemphigoid (BP)
Hu YQ, Zhang JZ
doaj
Selective Targeting of IL‐1RAP‐Dependent Eosinophilic Inflammation in Allergic Fungal Airway Disease
Allergy, EarlyView.
Thomas J. Williams +7 more
wiley +1 more source
Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions
Allergy, Volume 81, Issue 2, Page 326-344, February 2026.ABSTRACT Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment ...
Marjolein S. de Bruin‐Weller +9 more
wiley +1 more source
Potential of alarmin-targeted bispecific and combination therapies in airway disease
Frontiers in AllergyThymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are epithelial-derived proinflammatory alarmin cytokines that drive inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD).
H. Kiyomi Komori, Hector Ortega
doaj +1 more source
木村病においてはTSLP, TSLP受容体の発現が亢進している [PDF]
, 2015 博士（医学） 乙第2870号（主論文の要旨、要約、審査結果の要旨）博士（医学 ...
崎谷 恵理
core +1 more source
Clinical and Molecular Effect of the Anti–IL‐18 Antibody Aletekitug in Adults With Atopic Dermatitis
Allergy, Volume 81, Issue 2, Page 539-551, February 2026.At Week 12, aletekitug was associated with a −68.3% percentage change from baseline in EASI score. Aletekitug improved the transcriptional profile of lesional skin towards that of non‐lesional skin at Week 4 and Week 12. Aletekitug was well‐tolerated; no serious adverse event or death occurred, and no patient withdrew due to an adverse event.
Joanne Ellis +32 more
wiley +1 more source